Study Suggests Genetics as a Cause, Not Just a Risk, for Some Alzheimer’s

Pam Belluck reports via the New York Times: Scientists are proposing a new way of understanding the genetics of Alzheimer’s that would mean that up to a fifth of patients would be considered to have a genetically caused form of the disease. Currently, the vast majority of Alzheimer’s cases do not have a clearly identified cause. The new designation, proposed in a study published Monday, could broaden the scope of efforts to develop treatments, including gene therapy, and affect the design of clinical trials. It could also mean that hundreds of thousands of people in the United States alone could, if they chose, receive a diagnosis of Alzheimer’s before developing any symptoms of cognitive decline, although there currently are no treatments for people at that stage. The new classification would make this type of Alzheimer’s one of the most common genetic disorders in the world, medical experts said.

“This reconceptualization that we’re proposing affects not a small minority of people,” said Dr. Juan Fortea, an author of the study and the director of the Sant Pau Memory Unit in Barcelona, Spain. “Sometimes we say that we don’t know the cause of Alzheimer’s disease,” but, he said, this would mean that about 15 to 20 percent of cases “can be tracked back to a cause, and the cause is in the genes.” The idea involves a gene variant called APOE4. Scientists have long known that inheriting one copy of the variant increases the risk of developing Alzheimer’s, and that people with two copies, inherited from each parent, have vastly increased risk.

The new study, published in the journal Nature Medicine, analyzed data from over 500 people with two copies of APOE4, a significantly larger pool than in previous studies. The researchers found that almost all of those patients developed the biological pathology of Alzheimer’s, and the authors say that two copies of APOE4 should now be considered a cause of Alzheimer’s — not simply a risk factor. The patients also developed Alzheimer’s pathology relatively young, the study found. By age 55, over 95 percent had biological markers associated with the disease. By 65, almost all had abnormal levels of a protein called amyloid that forms plaques in the brain, a hallmark of Alzheimer’s. And many started developing symptoms of cognitive decline at age 65, younger than most people without the APOE4 variant.

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Minor Car Crashes Mean High Tech Repairs

“With all the improvements in car safety over the decades, the recent addition of a plethora of high tech sensors and warnings comes with increased costs,” writes longtime Slashdot reader smooth wombat. “And not just to have to have them on your car. Any time you get into an accident, even a minor one, it will most likely require a detailed examination of any sensors which may have been affected and their subsequent realignment, replacement, and calibration.” CNN reports: Some vehicles require “dynamic calibration,” which means, once the sensors and cameras are back in place, a driver needs to take the vehicle out on real roads for testing. With proper equipment attached the car can, essentially, recalibrate itself as it watches lane lines and other markers. It requires the car to be driven for a set distance at a certain speed but weather and traffic can create problems. “If you’re in Chicago or L.A., good luck getting to that speed,” said [Hami Ebrahimi, chief commercial officer at Caliber] “or if you’re in Seattle or Chicago or New York, with snow, good luck picking up all the road markings.”

More commonly, vehicles need “static calibration,” which can be done using machinery inside a closed workshop with a flat, level floor. Special targets are set up around the vehicle at set distances according to instructions from the vehicle manufacturer. “The car [views] those targets at those specific distances to recalibrate the world into the car’s computer,” Ebrahimi said. These kinds of repairs also demand buildings with open space that meet requirements including specific colors and lighting. And it requires special training for employees to perform these sorts of recalibrations, he said

“The change that we’ve seen in the last five years is greater than we’ve seen, probably, in the last five decades,” said Todd Dillender, chief operating officer of Caliber Collision, one of the biggest auto body repair companies in the United States with more than 1,700 locations across 41 states. […] With a rapidly changing industry, qualified auto body repair technicians are in short supply, just as they are in the engine repair business. That’s also led to upward pressure on pay in the industry as technicians have to be highly qualified and educated, Dillender said. That’s good for people who work in the industry, of course, but tougher for those who pay, and for the insurance companies who, in turn, pay for the repairs. A new study from consumer automotive group AAA says the cost to fix sensors and cameras in new vehicles “now accounts for more than a third of the post-crash repair costs,” reports CNN. However, “no one, including AAA, recommends not getting these features because of repair costs,” since many of them can cut crash rates in half and improve a car’s overall safety.

“They’re not going to prevent everything,” said Greg Brannon, director of automotive engineering at AAA. “And when you are in a crash, there are additional costs so it’s sort of the old ‘there’s no free ride’ when it comes to these things.”

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Stockholm Exergi Lands World’s Largest Permanent Carbon Removal Deal With Microsoft

Swedish energy company Stockholm Exergi and Microsoft have announced a 10-year deal that will provide the tech giant with more than 3.3 million tons of carbon removal certificates through bioenergy with carbon capture and storage. While the value of the deal was not disclosed, it stands as the largest of its kind globally. Carbon Herald reports: Scheduled to commence in 2028 and span a decade, the agreement underscores a pivotal moment in combatting climate change. Anders Egelrud, CEO of Stockholm Exergi, lauded the deal as a “huge step” for the company and its BECCS project, emphasizing its profound implications for climate action. “I believe the agreement will inspire corporations with ambitious climate objectives, and we target to announce more deals with other pioneering companies over the coming months,” he said. Recognizing the imperative of permanent carbon removals in limiting global warming to 1.5C or below, the deal aligns with Microsoft’s ambitious goal of becoming carbon negative by 2030.

“Leveraging existing biomass power plants is a crucial first step to building worldwide carbon removal capacity,” Brian Marrs, Microsoft’s Senior Director of Energy & Carbon Removal, said, highlighting the importance of sustainable biomass sourcing for BECCS projects, as is the case with Stockholm Exergi. The partners will adhere to stringent quality standards, ensuring transparent reporting and adherence to sustainability criteria. The BECCS facility, once operational, will remove up to 800,000 tons of carbon dioxide (CO2) annually, contributing significantly to atmospheric carbon reduction. With environmental permits secured and construction set to commence in 2025, Stockholm Exergi plans to reach the final investment decision by the end of the year.

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Google Fit Dev APIs Shutdown Set, Fate of Android and Wear OS Apps Go Unannounced

Abner Li reports via 9to5Google: Since the launch of Health Connect in 2022, Google has been winding down the Google Fit developer APIs. Earlier this week, the company fully detailed how the “Google Fit APIs have been deprecated and will be supported until June 30, 2025.” Fitness and exercise apps that previously used Google Fit have until the June 2025 deadline to switch to Health Connect, with Google broadly referring to it as the “Android Health platform.”

Google’s migration guide for developers lists what they’re supposed to switch to on Android phones and Wear OS. However, there is no replacement for the Goals API that lets Google Fit users set “how many steps and heart points they want to aim for each day.” Google says it will “share more details about what’s next for Android Health” at I/O later this month.

As of this API shutdown announcement, Google has said nothing about the Google Fit apps on Android, Wear OS, and iOS. They still work to track activity and house your full archive. […] At this point, it’s clear that Google Fit is not the future. On the Pixel Watch, Fitbit is the default, while Samsung and other Wear OS manufacturers have their own health tracking solutions. If Google were to announce a deprecation of the Fit app, having it coincide with the June 2025 developer deadline makes sense.

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Novel Attack Against Virtually All VPN Apps Neuters Their Entire Purpose

Researchers have discovered a new attack that can force VPN applications to route traffic outside the encrypted tunnel, thereby exposing the user’s traffic to potential snooping or manipulation. This vulnerability, named TunnelVision, is found in almost all VPNs on non-Linux and non-Android systems. It’s believe that the vulnerability “may have been possible since 2002 and may already have been discovered and used in the wild since then,” reports Ars Technica. From the report: The effect of TunnelVision is “the victim’s traffic is now decloaked and being routed through the attacker directly,” a video demonstration explained. “The attacker can read, drop or modify the leaked traffic and the victim maintains their connection to both the VPN and the Internet.” The attack works by manipulating the DHCP server that allocates IP addresses to devices trying to connect to the local network. A setting known as option 121 allows the DHCP server to override default routing rules that send VPN traffic through a local IP address that initiates the encrypted tunnel. By using option 121 to route VPN traffic through the DHCP server, the attack diverts the data to the DHCP server itself. […]

The attack can most effectively be carried out by a person who has administrative control over the network the target is connecting to. In that scenario, the attacker configures the DHCP server to use option 121. It’s also possible for people who can connect to the network as an unprivileged user to perform the attack by setting up their own rogue DHCP server. The attack allows some or all traffic to be routed through the unencrypted tunnel. In either case, the VPN application will report that all data is being sent through the protected connection. Any traffic that’s diverted away from this tunnel will not be encrypted by the VPN and the Internet IP address viewable by the remote user will belong to the network the VPN user is connected to, rather than one designated by the VPN app.

Interestingly, Android is the only operating system that fully immunizes VPN apps from the attack because it doesn’t implement option 121. For all other OSes, there are no complete fixes. When apps run on Linux there’s a setting that minimizes the effects, but even then TunnelVision can be used to exploit a side channel that can be used to de-anonymize destination traffic and perform targeted denial-of-service attacks. Network firewalls can also be configured to deny inbound and outbound traffic to and from the physical interface. This remedy is problematic for two reasons: (1) a VPN user connecting to an untrusted network has no ability to control the firewall and (2) it opens the same side channel present with the Linux mitigation. The most effective fixes are to run the VPN inside of a virtual machine whose network adapter isn’t in bridged mode or to connect the VPN to the Internet through the Wi-Fi network of a cellular device. You can learn more about the research here.

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Microsoft’s ‘Responsible AI’ Chief Worries About the Open Web

From the Washington Post’s “Technology 202” newsletter:

As tech giants move toward a world in which chatbots supplement, and perhaps supplant, search engines, the Microsoft executive assigned to make sure AI is used responsibly said the industry has to be careful not to break the business model of the wider web. Search engines citing and linking to the websites they draw from is “part of the core bargain of search,” [Microsoft’s chief Responsible AI officer] said in an interview Monday….

“It’s really important to maintain a healthy information ecosystem and recognize it is an ecosystem. And so part of what I will continue to guide our Microsoft teams toward is making sure that we are citing back to the core webpages from which the content is sourced. Making sure that we’ve got that feedback loop happening. Because that is part of the core bargain of search, right? And I think it’s critical to make sure that we are both providing users with new engaging ways to interact, to explore new ideas — but also making sure that we are building and supporting the great work of our creators.”

Asked about lawsuits alleging copyright use without permission, they said “We believe that there are strong grounds under existing laws to train models.”

But they also added those lawsuits are “asking legitimate questions” about where the boundaries are, “for which the courts will provide answers in due course.”

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Scientists Find a ‘Missing Link’ Between Poor Diet and Higher Cancer Risk

Science Alert reports that a team of researchers found “that changes in glucose metabolism could help cancer grow by temporarily disabling a gene that protects us from tumors called BRCA2.”

The team first examined people who inherited one faulty copy of BRCA2. They found that cells from these people were more sensitive to methylglyoxal (MGO), which is produced when cells break down glucose for energy in the process of glycolysis. Glycolysis generates over 90 percent of the MGO in cells, which a pair of enzymes typically keep to minimal levels. In the event they can’t keep up, high MGO levels can lead to the formation of harmful compounds that damage DNA and proteins. In conditions like diabetes, where MGO levels are elevated due to high blood sugar, these harmful compounds contribute to disease complications.

The researchers discovered that MGO can temporarily disable the tumor-suppressing functions of the BRCA2 protein, resulting in mutations linked to cancer development…

As the BRCA2 allele isn’t permanently inactivated, functional forms of the protein it produces can later return to normal levels. But cells repeatedly exposed to MGO may continue to accumulate cancer-causing mutations whenever existing BRCA2 protein production fails. Overall, this suggests that changes in glucose metabolism can disrupt BRCA2 function via MGO, contributing to the development and progression of cancer…

This new information may lead to strategies for cancer prevention or early detection. “Methylglyoxal can be easily detected by a blood test for HbA1C, which could potentially be used as a marker,” Venkitaraman says. “Furthermore, high methylglyoxal levels can usually be controlled with medicines and a good diet, creating avenues for proactive measures against the initiation of cancer.”

Their research has been published in Cell.

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Can Technology Help Reduce Drunk-Driving Deaths?

An anonymous reader shared this report from the Wall Street Journal:
Drunken-driving deaths in the U.S. have risen to levels not seen in nearly two decades, federal data show, a major setback to long-running road-safety efforts. At the same time, arrests for driving under the influence have plummeted, as police grapple with challenges like hiring woes and heightened concern around traffic stops… About 13,500 people died in alcohol impairment-related crashes in 2022, according to data released in April by the National Highway Traffic Safety Administration. That is 33% above 2019’s toll and on par with 2021’s. The last time so many people died as a result of accidents involving intoxicated drivers was in 2006.
That’s still down from the early 1980s, when America was seeing over 20,000 drunk-driving deaths a year, according to the article. “By 2010, that number had fallen to around 10,000 thanks to high-profile public-education campaigns by groups like MADD, tougher laws, and aggressive enforcement that included sobriety checkpoints and typically yielded well over a million DUI arrests annually.”
But some hope to solve the problem using technology:
Many activists and policymakers are banking on the promise of built-in devices to prevent a car from starting if the driver is intoxicated, either by analyzing a driver’s exhaled breath or using skin sensors to gauge the blood-alcohol level. NHTSA issued a notice in December that it said lays the groundwork for potential alcohol-impairment detection technology standards in all new cars “when the technology is mature.”
And Glenn Davis, who manages Colorado’s highway-safety office, “pointed to Colorado’s extensive use of ignition interlock systems that require people convicted of DUI to blow into a tube to verify they are sober in order for their car to start. He said the office promotes nondriving options such as Lyft and Uber.”

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Multinational ISP Offers $206M In Secured Notes Backed By IPv4 Addresses

CircleID reports that Multinational internet service provider Cogent recently announced that it was offering $206 million in secured notes (a corporate bond backed by assets). “The unusual part is what it’s using as security: some of its IPv4 addresses and the leases on those IPv4 addresses.”

All internet service providers (ISPs) give IP addresses to their users, but Cogent was among the first to lease those addresses independently of internet access. (Internet access customers normally require a unique address as part of their service.) Sources are hard to find, but prevailing wisdom is that they have over 10M addresses leased for about $0.30 per month, or $36M per year in revenue.
The notes are expected to be repaid in five years.

Thanks to long-time Slashdot reader penciling_in for sharing the article.

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U.S. Seeks to Build World Pressure on Russia Over Space Nuclear Weapon

An anonymous reader shared this report from the New York Times:

American officials are trying to increase international pressure on Russia not to deploy an antisatellite nuclear weapon in space, and have obtained information that undermines Moscow’s explanation that the device it is developing is for peaceful scientific purposes, a senior State Department official said on Friday…

On Friday, Mallory Stewart, the assistant secretary of state for arms control, said that while the United States had been aware of Russia’s pursuit of such a device for years, “only recently have we been able to make a more precise assessment of their progress.” Ms. Stewart, speaking at the nonpartisan Center for Strategic and International Studies in Washington, said the orbit the Russian satellite would occupy is in a high-radiation region not used by other satellites, information that undercuts Russia’s defense that it is not developing a weapon.

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