$500 Drone Calculates Its GPS Coordinates Offline from Downloaded Google Maps and a Camera

From a report:

A team of drone enthusiasts have built a sub-$500 drone that uses a camera and Google Maps to provide itself with GPS co-ordinates, removing the need for a GPS satellite signal. And all of this was done in 24 hours during the El Segundo Defense Tech Hackathon. The drone the trio opted for is a custom designed and 3D printed fixed wing featuring a large single motor towards the rear and a downward facing camera used for geo-referencing…

Doesn’t Google Maps still require internet, you may ask? Google Maps allows users to download segments of maps ahead of time, usually for use when you are travelling or camping out in remote areas. In this instance, the team used this feature to their advantage, allowing the drone to continue operating…

Thanks to long-time Slashdot reader schwit1 for sharing the news.

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Scientists Pursue Cancer Vaccines Tailored to the Genetic Makeup of an Individual’s Tumor

“The Royal Swedish Academy of Sciences, which selects Nobel laureates in chemistry and physics, last week awarded Dr. Wu its Sjöberg Prize in honor of ‘decisive contributions’ to cancer research,” reports CNN.

Their profile of the oncologist from Boston’s Dana-Farber Cancer Institute notes Dr. Wu’s research “has laid the scientific foundation for the development of cancer vaccines tailored to the genetic makeup of an individual’s tumor.”

It’s a strategy looking increasingly promising for some hard-to-treat cancers such as melanoma and pancreatic cancer, according to the results of early-stage trials, and may ultimately be widely applicable to many of the 200 or so forms of cancer…

The most common treatments for cancer — radiation therapy and chemotherapy — are like sledgehammers, striking all cells and often damaging healthy tissue. Since the 1950s, cancer researchers have been seeking a way to dial up the body’s immune system, which naturally tries to fight cancer but is outsmarted by it, to attack tumor cells. Progress on that front was middling until about 2011 with the arrival of a class of drugs called checkpoint inhibitors, which boost the anti-tumor activity of T cells, an important part of the immune system… These drugs have helped some people with cancer who would have been given months to live survive for decades, but they don’t work for all cancer patients, and researchers continue to look for ways to turbocharge the body’s immune system against cancer…

Wu’s research focused on small mutations in cancer tumor cells. These mutations, which occur as the tumor grows, create proteins that are slightly different to those in healthy cells. The altered protein generates what’s called a tumor neoantigen that can be recognized by the immune system’s T cells as foreign, and therefore susceptible to attack. With thousands of potential neoantigen candidates, Wu used “tour de force lab work” to identify the neoantigens that are on the cell surface, making them a potential target for a vaccine, said Urban Lendahl, professor of genetics at the Karolinska Institutet in Sweden and the secretary of the committee that awarded the prize. “If the immune system is to have a chance to attack the tumor, this difference must be manifested on the surface of the tumor cells. Otherwise, it’s pretty pointless,” Lendahl added…

By sequencing DNA from healthy and cancer cells, Wu and her team identified a cancer patient’s unique tumor neoantigens. Synthetic copies of these unique neoantigens could be used as a personalized vaccine to activate the immune system to target the cancer cells… Once it had FDA approval, the team vaccinated six patients with advanced melanoma with a seven-shot course of patient-specific neoantigens vaccines. The breakthrough results were published in an 2017 article in Nature. For some patients, this treatment resulted in the immune system’s cells being activated and targeting the tumor cells. The results, along with another paper published the same year led by the founders of mRNA vaccine company BioNTech, provided “proof of principle” that a vaccine can be targeted to a person’s specific tumor, Lendahl said.

A follow-up by Wu’s team four years after the patients received the vaccines published in 2021, showed that the immune responses were effective in keeping cancer cells under control… Since then, Wu’s team, other groups of medical researchers and pharmaceutical companies, including Merck, Moderna and BioNTech, have further developed this field of research, with trials underway for vaccines that treat pancreatic and lung cancer as well as melanoma.

“All the trials underway are small-scale, typically involving a handful of patients with later-stage disease and a high tolerance for safety risks,” adds CNN.

“To show that these type of cancer vaccines work, much larger randomized control trials are needed.”

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Boeing Removes Head of Its 737 Max Program After January’s ‘Door Bolts’ Incident

On Wednesday Boeing “removed executive Ed Clark, the head of its 737 Max passenger jet program,” reports CNN, “after a dramatic — and terrifying — midair blowout in January underscored ongoing problems with the jet.”

A preliminary report by the National Transportation Safety Board found that the four bolts that should have held the door plug in place were missing when the plane left Boeing’s factory. The NTSB report did not assess blame for the missing bolts and the accident but in a statement to investors before the findings were released, Boeing CEO Dave Calhoun assumed responsibility for the incident. “We caused the problem, and we understand that,” he told investors during a call after reporting the latest quarterly loss at the company. “Whatever conclusions are reached, Boeing is accountable for what happened.”

Clark, who had been at Boeing for 18 years, had only been in charge of the Max program since March of 2021, assuming that title after the jets had been returned to service following the crashes. But he had previously held roles related to the 737 Max, including as chief engineer and chief 737 mechanic.

With the news of Clark’s departure, Boeing also announced a shuffling of a number of executives in its Boeing Commercial Airplanes unit. It created a new executive position, Senior Vice President for BCA Quality, and named Elizabeth Lund to that position.

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License Plate-Scanning Company Violates Privacy of Millions of California Drivers, Argues Class Action

“If you drive a car in California, you may be in for a payday thanks to a lawsuit alleging privacy violations by a Texas company,” report SFGate:

The 2021 lawsuit, given class-action status in September, alleges that Digital Recognition Network is breaking a California law meant to regulate the use of automatic license plate readers. DRN, a Fort Worth-based company, uses plate-scanning cameras to create location data for people’s vehicles, then sells that data to marketers, car repossessors and insurers.

What’s particularly notable about the case is the size of the class. The court has established that if you’re a California resident whose license plate data was collected by DRN at least 15 times since June 2017, you’re a class member. The plaintiff’s legal team estimates that the tally includes about 23 million people, alleging that DRN cameras were mounted to cars on public roads. The case website lets Californians check whether their plates were scanned.

Barring a settlement or delay, the trial to decide whether DRN must pay a penalty to those class members will begin on May 17 in San Diego County Superior Court…

The company’s cameras scan 220 million plates a month, its website says, and customers can use plate data to “create comprehensive vehicle stories.”

A lawyer for the firm representing class members told SFGATE Friday that his team will try to show DRN’s business is a “mass surveillance program.”

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Florida Lawmakers Pass Ban On Social Media For Kids

Florida lawmakers passed a bill on Thursday that forces social media companies to keep most minors off their platforms. The Hill reports: The legislation, which passed the state House Thursday after earlier being approved by the Senate, now heads to Gov. Ron DeSantis’s (R) desk, though he says he’s not quite ready to sign on. DeSantis told reporters Friday that he thinks there needs to be a “proper balance” between government regulations and parental input on the social media issue. “We’ll be wrestling with that,” he said. The governor said he’ll be assessing the final version of the legislation likely through the weekend. “Federal law says 13 and under can’t have social media accounts. That’s not really enforced,” he said.

The lawmakers who championed the proposed social media ban, which would require platforms check the ages of users through a third-party source, argue it will make the online landscape safer for youths. The legislation passed 108-7 in the state House and 23-14 in the Florida Senate within a matter of hours Thursday.

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Microplastics Found In Sediment Layers Untouched By Modern Humans

Microplastics have been found in sediment layers that date back as early as the first half of the 1700s, “showing microplastics’ pernicious ability to infiltrate even environments untouched by modern humans,” reports Futurism. From the report: A team of European researchers made this alarming discovery after studying the sediment layers at three lakes in Latvia, as detailed in a study published in the journal Science Advances. The scientists were studying lake sediment to test if the presence of microplastics in geological layers would be a reliable indicator for the beginning of the Anthropocene Epoch, defined in the study as starting in 1950 and meant to delineate when humans started having a large impact on our environment.

Scientists have long used layers of ash or ice to study past events on Earth, leading to the question of whether microplastics can serve as a reliable chronological marker for the Anthropocene. Clearly not, according to this new research, which found microplastics in every layer of sediment they dredged up, including one from 1733. “We conclude that interpretation of microplastics distribution in the studied sediment profiles is ambiguous and does not strictly indicate the beginning of the Anthropocene Epoch,” the scientists wrote.

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Former Gizmodo Writer Changed Name To ‘Slackbot,’ Stayed Undetected For Months

Tom McKay successfully masqueraded as a “Slackbot” on Slack after leaving Gizmodo in 2022, going unnoticed by the site’s management for several months. The Verge reports: If you’re not glued to Slack for most of the day like I am, then you might not know that Slackbot is the friendly robot that lives in the messaging service. It helps you do things like set reminders, find out your office’s Wi-Fi password, or let you know when you’ve been mentioned in a channel that you’re not a part of. When it was his time to leave, McKay swapped out his existing profile picture for one that resembled an angrier version of Slackbot’s actual icon. He also changed his name to “Slackbot.” You can’t just change your name on Slack to “Slackbot,” by the way, as the service will tell you that name’s already been taken. It does work if you use a special character that resembles one of the letters inside Slackbot, though, such as replacing “o” with the Unicode character “o.”

The move camouflaged McKay’s active Slack account for months, letting his account evade deletion. It also allowed him to send bot-like messages to his colleagues such as, “Slackbot fact of the day: Hi, I’m Slackbot! That’s a fact. Have a Slack-ly day!” My colleague Victoria Song, who previously worked at Gizmodo, isn’t all that surprised that this situation unfolded, and says, “As Tom’s former coworker and a G/O Media survivor, this tracks.”

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Reddit Files To Go Public

Reddit has filed its initial public offering (IPO) with the SEC on Thursday. “The company plans to trade on the New York Stock Exchange under the ticker symbol ‘RDDT,'” reports CNBC. From the report: Its market debut, expected in March, will be the first major tech initial public offering of the year. It’s the first social media IPO since Pinterest went public in 2019. Reddit said it had $804 million in annual sales for 2023, up 20% from the $666.7 million it brought in the previous year, according to the filing. The social networking company’s core business is reliant on online advertising sales stemming from its website and mobile app.

The company, founded in 2005 by technology entrepreneurs Alexis Ohanian and Steve Huffman, said it has incurred net losses since its inception. It reported a net loss of $90.8 million for the year ended Dec. 31, 2023, compared with a net loss of $158.6 million the year prior. […] Reddit said it plans to use artificial intelligence to improve its ad business and that it expects to open new revenue channels by offering tools and incentives to “drive continued creation, improvements, and commerce.” It’s also in the early stages of developing and monetizing a data-licensing business in which third parties would be allowed to access and search data on its platform.

For example, Google on Thursday announced an expanded partnership with Reddit that will give the search giant access to the company’s data to, among other uses, train its AI models. “In January 2024, we entered into certain data licensing arrangements with an aggregate contract value of $203.0 million and terms ranging from two to three years,” Reddit said, regarding its data-licensing business. “We expect a minimum of $66.4 million of revenue to be recognized during the year ending December 31, 2024 and the remaining thereafter.” On Wednesday, Reddit said it plans to sell a chunk of its IPO shares to 75,000 of its most loyal users.

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US Lands Unmanned ‘Odysseus’ Spacecraft On Moon

The first privately built spacecraft has successfully landed on the lunar surface on Thursday. “We can confirm, without a doubt, that our equipment is on the surface of the moon,” said Stephen Altemus, CEO of Intuitive Machines, the Houston-based company that operated the Odysseus spacecraft. “Welcome to the moon.” From a report: As it approached the surface of the moon, Odysseus lost contact with NASA, resulting in several anxious minutes for those who worked on the joint project. But after approximately 15 minutes of searching, officials confirmed that they were once again receiving signals from the spacecraft. “A commercial lander named Odysseus, powered by a company called Intuitive Machines, launched up on a Space X rocket, carrying a bounty of NASA scientific instruments and bearing the dream of a new adventure, a new adventure in science, innovation and American leadership, well, all of that aced the landing of a lifetime,” NASA Administrator Bill Nelson said after contact had been reestablished. “Today for the first time in more than a half century, the U.S. has returned to the moon.”

Altemus had estimated that Odysseus had an 80% chance of successfully landing on the moon, citing previous failed attempts as an advantage. “We’ve stood on the shoulders of everybody who’s tried before us,” Altemus said. It was the first American mission to land on the moon since Apollo 17 in 1972 and the first private spacecraft ever to make a soft landing there. While it was a private mission, NASA paid Intuitive Machines $118 million to deliver six instruments to the moon. And the U.S. space agency provided streaming video of the landing.

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