Why Chemists Can’t Quit Palladium

A retracted paper highlights chemistry’s history of trying to avoid the expensive, toxic — but necessary — catalyst. From a report: It’s hard to find a place on Earth untouched by palladium. The silvery-white metal is a key part of catalytic converters in the world’s 1.4 billion cars, which spew specks of palladium into the atmosphere. Mining and other sources add to this pollution. As a result, traces of palladium show up in some of the most remote spots on Earth, from Antarctica to the top of the Greenland ice sheet. Palladium is also practically indispensable for making drugs. That’s because catalysts with palladium atoms at their core have an unmatched ability to help stitch together carbon –carbon bonds. This kind of chemical reaction is key to building organic molecules, especially those used in medications.

“Every pharmaceutical we produce at some point or another has a palladium-catalysed step in it,” says Per-Ola Norrby, a pharmaceutical researcher at drug giant AstraZeneca in Gothenburg, Sweden. Palladium-catalysed reactions are so valuable that, in 2010, their discoverers shared a Nobel prize. But despite its versatility, chemists are trying to move away from palladium. The metal is more expensive than gold, and molecules that contain palladium can also be extremely toxic to humans and wildlife. Chemical manufacturers have to separate out all traces of palladium from their products and carefully dispose of the hazardous waste, which adds extra expense. Thomas Fuchb, a medicinal chemist at the life-sciences company Merck in Darmstadt, Germany, gives the example of a reaction to make 3 kilograms of a drug molecule for which the ingredients cost US$250,000. The palladium catalyst alone adds $100,000; purifying it out of the product another $30,000.

Finding less-toxic alternatives to the metal could help to reduce environmental harm from palladium waste and move the chemicals industry towards ‘greener’ reactions, says Tianning Diao, an organometallic chemist at New York University. Researchers hope to swap palladium for more common metals, such as iron and nickel, or invent metal-free catalysts that sidestep the issue altogether. Several times in the past two decades, researchers have reported finding palladium-free catalysts. But in what has become a recurring pattern for the field, each heralded discovery turned out to be a mistake.

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The Collapse of Complex Software

Nolan Lawson, writing in a blogpost: Anyone who’s worked in the tech industry for long enough, especially at larger organizations, has seen it before. A legacy system exists: it’s big, it’s complex, and no one fully understands how it works. Architects are brought in to “fix” the system. They might wheel out a big whiteboard showing a lot of boxes and arrows pointing at other boxes, and inevitably, their solution is… to add more boxes and arrows. Nobody can subtract from the system; everyone just adds. This might go on for several years. At some point, though, an organizational shakeup probably occurs — a merger, a reorg, the polite release of some senior executive to go focus on their painting hobby for a while. A new band of architects is brought in, and their solution to the “big diagram of boxes and arrows” problem is much simpler: draw a big red X through the whole thing. The old system is sunset or deprecated, the haggard veterans who worked on it either leave or are reshuffled to other projects, and a fresh-faced team is brought in to, blessedly, design a new system from scratch.

As disappointing as it may be for those of us who might aspire to write the kind of software that is timeless and enduring, you have to admit that this system works. For all its wastefulness, inefficiency, and pure mendacity (“The old code works fine!” “No wait, the old code is terrible!”), this is the model that has sustained a lot of software companies over the past few decades. Will this cycle go on forever, though? I’m not so sure. Right now, the software industry has been in a nearly two-decade economic boom (with some fits and starts), but the one sure thing in economics is that booms eventually turn to busts. During the boom, software companies can keep hiring new headcount to manage their existing software (i.e. more engineers to understand more boxes and arrows), but if their labor force is forced to contract, then that same system may become unmaintainable. A rapid and permanent reduction in complexity may be the only long-term solution.

One thing working in complexity’s favor, though, is that engineers like complexity. Admit it: as much as we complain about other people’s complexity, we love our own. We love sitting around and dreaming up new architectural diagrams that can comfortably sit inside our own heads — it’s only when these diagrams leave our heads, take shape in the real world, and outgrow the size of any one person’s head that the problems begin. It takes a lot of discipline to resist complexity, to say “no” to new boxes and arrows. To say, “No, we won’t solve that problem, because that will just introduce 10 new problems that we haven’t imagined yet.” Or to say, “Let’s go with a much simpler design, even if it seems amateurish, because at least we can understand it.” Or to just say, “Let’s do less instead of more.”

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Monkeypox Outbreak Poses ‘Real Risk’ To Public Health, WHO Official Says

The World Health Organization’s top official in Europe on Wednesday called for urgent action by the authorities and civic groups to control fast-rising cases of monkeypox that he said posed a real risk to public health. From a report: Europe has emerged as the epicenter of an outbreak of monkeypox, with more than 1,500 cases identified in 25 European countries, which account for 85 percent of global cases, the official, Dr. Hans Kluge, the W.H.O.’s director of its European region, said at a news conference. The W.H.O. will convene its emergency committee in Geneva next week, Dr. Kluge added, to determine if the outbreak constitutes a public health emergency of international concern, a formal declaration that calls for a coordinated response between countries.

“The magnitude of this outbreak poses a real risk,” Dr. Kluge said. “The longer the virus circulates, the more it will extend its reach, and the stronger the disease’s foothold will get in nonendemic countries.” Monkeypox is a viral infection endemic in West Africa, but it has now spread to 39 countries, including 32 that have no previous experience of it, the W.H.O. director, Dr. Tedros Adhanom Ghebreyesus, told reporters on Tuesday. Countries outside Africa and Europe that have identified cases of monkeypox include Australia, Brazil, Canada, Israel and the United States.

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Some Ads Play on Streaming Services Even When the TV Is Off, Study Finds

Many commercials continue to play on ad-supported streaming services after viewers turn off their television, new research shows, a problem that is causing an estimated waste of more than $1 billion a year for brands. From a report: The findings come as an ever-growing share of ad dollars is shifting from traditional TV to streaming platforms, a trend that is likely to accelerate now that industry giants Netflix and Walt Disney’s Disney+ have embraced the idea of offering an ad-supported version of their services. Some 17% of ads shown on televisions connected through a streaming device — including streaming boxes, dongles, sticks and gaming consoles — are playing while the TV is off, according to a study by WPP’s ad-buying giant GroupM and ad-measurement firm iSpot.tv.

That is because when a TV set is turned off, it doesn’t always send a signal to the streaming device connected to the TV through its HDMI port, GroupM said. As a result, the streaming device will continue playing the show and its ads unless users had exited or paused the streaming app they were watching before turning off their TV. Due to the nature of the problem, using a smart TV — on which streaming apps are loaded — makes it far less likely that ads would be shown while the TV is off, since in this instance the television and streaming device are just a single piece of hardware. GroupM said it found “virtually no incidence” of the issue on smart TV apps. The study, which included smart TVs and some hooked up with a streaming device, found that on average, between 8% and 10% of all streaming ads were shown while the TV was off.

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Signs Are Not Enough To Save Beachgoers from Deadly Currents

Keeping people out of rip currents is more about reading human behavior than reading warning signs. From a report: Worldwide, rips cause hundreds of drownings and necessitate tens of thousands of rescues every year. In Australia, where 85 percent of the population lives within an hour’s drive of the coast, rips cause more fatalities than floods, cyclones, and shark attacks combined. In 1938, one of the country’s most popular beaches, Sydney’s Bondi Beach, was the site of an infamous rip-current tragedy: within minutes, roughly 200 swimmers were swept away by a rip, leaving 35 people unconscious and five dead. More often, however, rips take one life at a time, garnering little media attention. For many casual beach visitors, the toll of rip currents goes unnoticed. […] Although almost three-quarters of beach users said they knew what a rip current is, only 54 percent could correctly define it. In addition, only half of the people she surveyed remembered seeing either the warning signs or the colored flags denoting surf conditions that were posted on or near the main access point to each beach. An even smaller percentage could recall what color the flags had been — green for calm, yellow for moderate, or red for dangerous conditions. “I was genuinely shocked,” Locknick says.

[…] Part of the challenge of preventing rip-related drownings stems from the lack of a simple method to escape them. Rip currents form when waves pile water near the shoreline. The water then gushes back out to sea, taking the path of least resistance. It might flow along channels carved in between sandbars or next to solid structures, such as jetties or rocky headlands. These types of rips can stick around year after year. Others are more erratic, creating fleeting bursts of seaward-flowing water on smooth, open beaches. People often mislabel rip currents as undertows or rip tides. Rip currents are not caused by tides, however, and undertows are a different, weaker current, formed when water pushed onto the beach moves back offshore along the seabed. Some telltale signs of a rip include a streak of churned-up, sandy water or a dark, flat gap between breaking waves.

It’s not surprising that rip currents are often misunderstood by the public because, for decades, beach-safety experts also had an oversimplified perception of their mechanics. In some of the earliest research on rips in the mid-20th century, American scientists watched sticks, pieces of kelp, and volleyballs float out to sea and described lanes of flowing water extending more than 300 meters offshore. This work formed the basis for the popular view of rip currents as jets flowing perpendicular to the beach, shooting out past the surf. To escape the river of current, experts recommended that bathers swim parallel to the beach — a message once broadcast through education campaigns and warning signs in the United States and Australia. As it turns out, that approach may not always work.

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US Defence Contractor in Talks To Take Over NSO Group’s Hacking Technology

The US defence contractor L3Harris is in talks to take over NSO Group’s surveillance technology, in a possible deal that would give an American company control over one of the world’s most sophisticated and controversial hacking tools. From a report: Multiple sources confirmed that discussions were centred on a sale of the Israeli company’s core technology â” or code â” as well as a possible transfer of NSO personnel to L3Harris. But any agreement still faces significant hurdles, including requiring the blessing of the US and Israeli governments, which have not yet given the green light to a deal. In a statement, a senior White House official said: “Such a transaction, if it were to take place, raises serious counterintelligence and security concerns for the US government.” If agreed, the deal would mark an astounding turnaround for NSO, less than a year after the Biden administration placed the company on a US blacklist and accused it of acting “contrary to the foreign policy and national security interests of the US.”

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Keychron’s Q3 Gives Mechanical Keyboard Fans Everything But the Numpad

An anonymous reader shares a review: In its early pre-pandemic days, Keychron made a name for itself with its series of affordable mechanical keyboards — including a few low-profile ones that remain a rarity to this day. Those boards didn’t necessarily appeal to enthusiasts, but were more than good enough for most mainstream users who wanted a different kind of keyboard. Last year, Keychron upped the ante with the launch of the Q1, an enthusiast-level, fully customizable hotswap keyboard with a 75% layout that had more than a few similarities to the heavily hyped GMMK Pro. Since then, Keychron has expanded this series with the 65% Q2, which received pretty rave reviews at the time and now the Q3.

The QMK-compatible Q3 clearly follows in the footsteps of the Q1 and Q2. It uses the same double-gasket design that should make for a relatively bouncy typing experience (though in my experience, there’s less bounce than I would’ve expected), and the overall design is pretty much the same, with the exception that it’s a tenkeyless (TKL), so you get a full keyboard with standalone arrow keys and a full row of function keys, but without the numpad. The body is made from aluminum and the whole unit weighs in at a hefty 4.5 pounds. In part, that’s because Keychron opted for a steel plate here. You can opt to get a bare-bones version where you supply your own switches and keycaps for $154 (or $164 if you want to get the optional volume knob), or a fully assembled version with keycaps and your choice of Gateron Pro Red, Blue or Brown switches for $174 (or $184 with knob). For the extra $20, I think getting the assembled version is a no-brainer, given that the keycaps and switches will cost you significantly more and even if you want to replace them, you could always reuse them in another project (because who only has one keyboard, right?).

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Email Client K-9 Mail Will Become Thunderbird for Android

The open source Thunderbird email client has a long and storied history, but until now, that history has been limited to the desktop. That’s about to change, according to a post on the Thunderbird blog. Thunderbird will be coming to Android through the popular open source mobile email client K-9 Mail. From a report: According to Thunderbird’s Jason Evangelho, the Thunderbird team has acquired the source code and naming rights to K-9 Mail. K-9 Mail project maintainer Christian Ketterer (who goes by “cketti” in the OSS community) will join the Thunderbird team, and over time, K-9 Mail will become Thunderbird for Android. Thunderbird’s team will invest finance and development time in K-9 to add several features and quality-of-life enhancements before that happens, though.

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Two Tech CEOs Wanted Every Worker to Have a Permanent, Publicly-Available Job Performance File

“Two CEOs on a podcast casually proposed a shareable database of worker performance that would follow them between companies, forever, and encouraged listeners to create one,” writes Slashdot reader merauder128 , summarizing a recent article on Vice.

“HR professionals say it’s a terrible idea.”

Vice points out the podcast both the host and guest were CEOs of “data harvesters that package and resell data to other parties.”
Through one lens, it was a mundane musing between two CEOs of data companies talking about how awesome it would be to have more data on something. But in the context of experiments occurring in the tech industry around hiring practices, it was two influential CEOs encouraging other entrepreneurs to create a business that would be an absolute nightmare for workers, a type of credit score for workers that could be a permanent HR file that follows workers from one job to the next, and where a worker who struggles at one job may have trouble getting another….

It is also in line with a growing trend among tech companies that, spurred by work-from-home and hybrid work, are increasingly interested in quantifying employee performance. The most prominent example is Coinbase introducing an app so employees can constantly rate each other’s performances, a scenario even the normally cheery TechCrunch said “sounds rough.”
Over the last several years, there has been a boom in employee management software solutions such as Workday, Lattice, CultureAmp that are used across thousands of companies for performance reviews and other sensitive HR tasks. Technologically speaking, what Youakim and Hoffman are talking about is opening those confidential resources — or some condensed version of them that can be easily digested and analyzed — up to everyone.

None of these HR software companies have indicated that they have any intention of doing this.
The article warns that experts who have studied hiring extensively believe a permanent database database “would allow this complete, random mess to follow workers their entire careers, affecting their job prospects, earning potential, and their broader lives.” And the article summarizes a reaction to the idea from John Hausknecht, a professor of human resources at Cornell University. “It assumes people don’t change, that jobs require similar attributes, that a person’s experience at one company is relevant to another where they will be in a different environment with a different manager and different company culture….

“Or, to put it a different way, ‘Just because we can track it, collect it, and ask about it,’ Hausknecht said, ‘doesn’t necessarily mean we should.'”

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Low-cost Astra Rocket Suffers Upper Stage Failure. Two NASA Satellites Lost

“All appeared to be going smoothly,” reports CBS News, “when, about a minute before the second stage engine was expected to shut down, an onboard ‘rocketcam’ showed a flash in the engine’s exhaust plume.

“The camera view them showed what appeared to be a tumble before video from the rocket cut off….”

California-based Astra on Sunday launched two shoebox-size NASA satellites from Cape Canaveral in a modest mission to improve hurricane forecasts, but the second stage of the company’s low-cost booster malfunctioned before reaching orbit and the payloads were lost.

“The upper stage shut down early and we did not deliver the payloads to orbit,” Astra tweeted. “We have shared our regrets with @NASA and the payload team. More information will be provided after we complete a full data analysis.”

It was the seventh launch of Astra’s small “Venture-class” rocket and the company’s fifth failure. Sunday’s launch was the first of three planned for NASA to launch six small CubeSats, two at a time, into three orbital planes. Given the somewhat risky nature of relying on tiny shoebox-size CubeSats and a rocket with a very short track record, the $40 million project requires just four satellites and two successful launches to meet mission objectives. The NASA contract calls for the final two flights by the end of July. Whether Astra can meet that schedule given Sunday’s failure is not yet known.

“Although today’s launch with @Astra did not go as planned, the mission offered a great opportunity for new science and launch capabilities,” tweeted NASA science chief Thomas Zurbuchen….
After Sunday’s failure, he tweeted: “Even though we are disappointed right now, we know: There is value in taking risks in our overall NASA Science portfolio because innovation is required for us to lead.”

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