Category: medicine

“Walking benefits nearly every cell in the body,” says Amanda Paluch, a kinesiologist and public health expert at UMass Amherst and the lead author of the study. It’s wildly effective. Walking strengthens your heart, improves bone density, relaxes your mind, and helps with muscle-building and pain management. Almost everyone can do it anywhere: your house, the office, outside. Start with 30 minutes and work your way up.”It’s not an all or nothing situation,” says Paluch. Even just boosting daily step count to 5,000 — for 60 and older — and 7,000 — for younger folks — slashed mortality risk by 40%.

One data field asks if a person died “from illness/complications of illness,” and the field next to this asks for the date of death. When the answer is yes, then the date of death should be provided. But a problem apparently arose if a respondent included the date of death in this field even when the answer was “no” or “unknown.” The CDC’s system assumed that if a date was provided, then the “no” or “unknown” answer was an error, and the system switched the answer to “yes.” This resulted in an overcount of deaths due to Covid in the demographic breakdown, and the error, once discovered, was corrected last week. The CDC did not answer a question on how long the coding error was in effect.

“Working with near real-time data in an emergency is critical to guide decision-making, but may also mean we often have incomplete information when data are first reported,” said Reed. The death counts in the data tracker are “real-time and subject to change,” Reed noted, while numbers from the National Center for Health Statistics, a center within the CDC, are “the most complete source of death data,” despite lags in reporting, because the process includes a review of death certificates.

The researchers had a handy way to see whether their reconstruction was accurate: Check the couples’ babies. They collected cheek swab samples from the babies and sequenced their full genome, just as they’d done with the parents. They then compared that “true sequence” with the reconstructed genome for the embryo from which the child originated. The comparison revealed, essentially, a match: For a 3-day-old embryo, at least 96% of the reconstructed genome aligned with the inherited gene variants in the corresponding baby; for a 5-day-old embryo, it was at least 98%. (Because much of the human genome is the same across all people, the researchers focused on the DNA variability that made the parents, and their babies, unique.) Once they had reconstructed embryo genomes in hand, the researchers turned to published data from large genomic studies of adults with or without common chronic diseases and the polygenic risk score models that were derived from that information. Then, MyOme applied those models to the embryos, crunching polygenic risk scores for 12 diseases, including breast cancer, coronary artery disease, and type 2 diabetes. The team also experimented with combining the reconstructed embryo sequence of single genes, such as BRCA1 and BRCA2, that are known to dramatically raise risk of certain diseases, with an embryo’s polygenic risk scores for that condition — in this case, breast cancer.

“The protection what we are getting from the third [doses], it is good enough — actually, quite good for hospitalizations and deaths,” Dr. Bourla said. But, “it’s not that good against infections” with omicron, and “it doesn’t last very long.” He reported that Pfizer is “working very diligently” to come up with a new dose that will protect against all variants and provide longer-lasting protection.

In the words of the researchers, who published their results in the CDC’s Morbidity and Mortality Weekly Report, the vaccine “did not reduce the risk for outpatient respiratory illness caused by influenza A(H3N2) viruses that have predominated so far this season.” Flu vaccines, even in a good year, are far from perfect. The strains of influenza virus that infect humans are constantly evolving, meaning that scientists have to try to predict what these strains will look like during the next flu season so that they can match them to the strains included in the vaccine (the vaccine will usually include four strains at a time). This guessing game often results in a vaccine that’s around 50% to 60% effective, but sometimes, as is the case this year, the mismatch can get worse. It doesn’t help that this year’s main flu is H3N2, a subtype of flu already known for being harder to predict than others.

The scientists from Florida State University and Duke University also found that 90% of children born in the U.S. between 1950 and 1981 had blood-lead levels higher than the CDC threshold. And the researchers found significant impact on cognitive development: on average, early childhood exposure to lead resulted in a 2.6-point drop in IQ. The researchers only examined lead exposure caused by leaded gasoline, the dominant form of exposure from the 1940s to the late 1980s, according to data from the U.S. Geological Survey. Leaded gasoline for on-road vehicles was phased out starting in the 1970s, then finally banned in 1996.

For now, sending commands to the device is cumbersome. Users must select their desired movement on a tablet, which sends Bluetooth commands to a transmitter worn around the waist. That device must be positioned next to a ‘pulse generator’ implanted in the abdomen, which then activates electrodes along the spine. Setting up to use the stimulation takes 5 to 10 minutes. But the next generation of devices should allow users to activate the pulse generator by giving voice commands to a smartwatch. The company behind the technology plans to test this newer mobility system in a multisite clinical trial of 70 to 100 participants that the team hopes will lead to U.S. regulatory approval. The researchers reported their findings in the journal Nature Medicine.

“A map showing stark differences in the incidence of 10 types of cancer between Spain and Portugal has sparked a race to pinpoint causes and risk factors people should avoid.”

It shows huge differences for people living only a short distance apart, sometimes across the border between Spain and Portugal, and others occurring within the same country. Scientists say it will take years to solve the puzzle completely but are confident that the map provides the pieces. There are easier questions and more complex riddles. But it all points to environmental factors — as opposed to genetics — playing a major role in causing cancers.

The lung cancer map tells a clear story of far higher levels of smoking tobacco in Spain than in Portugal, with the latter country showing a consistent hue of dark blue for a lower risk of mortality, while Spain has large areas lit up in red, at least on the map representing men. Twenty per cent of Spanish adults are daily smokers, compared with just over 11 per cent in Portugal. But the data from cancer of the larynx, also linked to smoking, tells a vastly different story, with a high mortality risk for men shown straddling the border in southern Portugal and south western Spain, as well as patches in the north of both countries. “The lung cancer and smoking connection is very clear, so why in other cancers that have a strong link with tobacco are we seeing such surprising differences?” asks Pablo Fernández-Navarro, the lead co-ordinator of the atlas from the Spanish side.

“This is what is so fantastic. If whole countries had uniform levels of mortality, the maps would be in plain colours. Given that it is not the case, now we have to investigate and explain these differences, eliminating one factor after another,” Fernández-Navarro told The Telegraph.

In the case of larynx cancer, the Spanish epidemiologist says the map confirms that smoking is by no means the only risk factor, and that other elements must also be at work, from alcohol intake to levels of pollutants such as asbestos or petrochemicals in the environment.

Thanks to Slashdot reader Bruce66423 for sharing the link.

The scientific panel emphasized that the cases it studied were “genuine and compelling,” noting that some incidents have affected multiple people in the same space and clinical samples from a few victims have shown signs of “cellular injury to the nervous system.” An executive summary of the panel’s work provided new details about how the government is categorizing cases as possible Havana Syndrome, a clinically vague illness that has long frustrated firm diagnosis because victims have suffered from such a diverse array of symptoms. Although officials declined to say how many cases the panel examined as part of its inquiry, they said they studied cases that met four “core characteristics”: the acute onset of sounds or pressure, sometimes in only one ear or on one side of the head; simultaneous symptoms of vertigo, loss of balance and ear pain; “a strong sense of locality or directionality”; and the absence of any known environmental or medical conditions that could have caused the other symptoms.

Both pulsed electromagnetic energy, “particularly in the radiofrequency range,” and ultrasonic arrays could feasibly cause the four core symptoms, the panel found. Both could originate from “a concealable source.” But ultrasound can’t travel through walls, the panel found, “restricting its applicability to scenarios in which the source is near the target.”
Sources of radiofrequency energy, on the other hand, are known to exist, “could generate the required stimulus, are concealable, and have moderate power requirements,” the panel said. “Using nonstandard antennas and techniques, the signals could be propagated with low loss through air for tens to hundreds of meters, and with some loss, through most building materials.” But intelligence officials familiar with the panel’s work emphasized that important information gaps remained, forestalling them from reaching firmer conclusions. The experts panel also ruled out so-called psycho-social factors. They also ruled out “ionizing radiation, chemical and biological agents, infrasound, audible sound, ultrasound propagated over large distances, and bulk heating from electromagnetic energy.”

“The panel made seven recommendations, including developing better biomarkers that are ‘more specific and more sensitive for diagnosis and triage’ of cases,” reports CNN. “It also recommended utilizing ‘detectors’ and obtaining ‘devices to aid research.’ Finally, officials urged swift action by medical officials whenever a case is reported, emphasizing that individuals who have been treated immediately after an event have improved.”