Category: medicine

U.S. Centers for Disease Control and Prevention (CDC) Director Rochelle Walensky said even with the seven-day average of COVID hospitalizations down 14% to 4,500 per day, annual shots could save thousands of lives. “Modeling projections show that an uptake of updated COVID-19 vaccine doses similar to an annual flu vaccine coverage early this fall could prevent as many as 100,000 hospitalizations and 9,000 deaths, and save billions of dollars in direct medical costs,” she said. The redesigned boosters, green-lighted by U.S. health regulators last week, aim to tackle the BA.5 and BA.4 Omicron subvariants, which account for over 88% and 11% of circulating viruses, respectively, Walensky said. The so-called bivalent vaccines also still target the original version of the virus.

Top U.S. infectious disease expert Dr. Anthony Fauci said unless a dramatically different variant emerges, annual vaccines should offer enough protection for most people, but that some vulnerable groups might need more frequent vaccinations. “We likely are moving towards a path with a vaccination cadence similar to that of the annual influenza vaccine, with annual, updated COVID-19 shots matched to the currently circulating strains for most of the population,” he said.

To create the implant, Lagali and his team dissolved pig tissue to form a purified collagen solution. That was used to engineer a hydrogel that mimics the human cornea. Surgeons then made an incision in a patient’s cornea for the hydrogel. “We insert our material into this pocket to thicken the cornea and to reshape it so that it can restore the cornea’s function,” Lagali said. Traditionally, human tissue is required for cornea transplants. But it’s in short supply, because people must volunteer to donate it after they die. So, Lagali said, his team was looking for a low-cost, widely available substitute. “Collagen from pigskin is a byproduct from the food industry,” he said. “This makes it broadly available and easier to procure.” After two years, the patients’ bodies hadn’t rejected the implants, and they didn’t have any inflammation or scarring.

But any experimental medical procedure comes with risk. In this case, Soiberman said, a foreign molecule like collagen could induce an immune reaction. The researchers prescribed patients an eight-week course of immunosuppressive eyedrops to lower the risk, which is less than the amount given to people who receive cornea transplants from human tissue. In those cases, patients take immunosuppressive medicine for more than a year, Lagali said. “There’s always a risk for rejection of the human donor tissue because it contains foreign cells,” he said. “Our implant does not contain any cells … so there’s a minimal risk of rejection.” The procedure itself was also quicker than traditional cornea transplants. The researchers said each operation took about 30 minutes, whereas transplants of human tissue can take a couple of hours. […] It’s not yet clear whether the surgery would work for patients who have other forms of corneal disease aside from keratoconus.

[…] To create it, Glowacki took aesthetic inspiration from quantum mechanics — as he puts it, “where the definition of what’s matter and what’s energy starts to become blurred.” For their paper, Glowacki and his collaborators measured the emotional response Isness-D elicited in 75 participants. They based their measurements on four metrics used in psychedelics research — the MEQ30 (a mystical experience questionnaire), the ego dissolution inventory scale, the “communitas” scale, and the “inclusion of community in self” scale. Communitas is defined as an experience of intense shared humanity that transcends social structure. Participants’ responses were then compared with those given in published, double-blind psychedelics studies. For all four metrics, Isness-D elicited responses indistinguishable from those associated with medium doses of psychedelics. On the mystical experience scale, Isness-D participants reported an experience as intense as that elicited by 20 milligrams of psilocybin or 200 micrograms of LSD, and stronger than that induced by microdoses of either substance. The findings have been published in the journal Nature Scientific Reports.

Ultimately, the trained dogs were more sensitive to positive cases. Nasal PCR tests were better able to better detect negative cases. In two false positive cases, dogs falsely identified other coronavirus respiratory illness strains that were not Covid. While there have been previous studies on the capability of dogs to detect Covid, this is believed to be the first to compare the accuracy of dogs to antigenic tests. The study has been published in the journal Plos One.

These findings are also supported by a separate analysis of 500,000 people in the United Kingdom that showed that those taking anti-inflammatory drugs to treat their pain were more likely to have pain two to ten years later, an effect not seen in people taking acetaminophen or anti-depressants. “Our findings suggest it may be time to reconsider the way we treat acute pain. Luckily pain can be killed in other ways that don’t involve interfering with inflammation,” says Massimo Allegri, a Physician at the Policlinico of Monza Hospital in Italy and Ensemble Hospitalier de la Cote in Switzerland.

The project — led by researchers at Sheffield University — builds on progress in two key medical fields. The first involves viruses that specifically attack tumours…. After infection with an oncolytic virus, a cancer cell will burst open and die. The US Food and Drug Administration has already approved the use of T-Vec, a modified herpes simplex virus that infects and kills tumour cells and is now being used to treat people with certain types of melanoma, a skin cancer.
Unfortunately, the viruses soon get attacked by the body’s immune system. So the scientists want to coat the viruses with magnetic particles, so that magnets (outside a patient’s body) can quickly guide those viruses where they’re needed.

And to accomplish this they’re using a soil bacteria which is known to make magnets to align with Earth’s own magnetic field. “The essence of this approach is straightforward,” one of the project’s leaders explains to the Guardian. “We are using bugs as drugs…. we have found bacteria do a better job of manufacturing them than we could.”
Having developed the technology, the Sheffield team is now working to ensure they can manufacture sufficient supplies so that clinical trials on humans can begin soon. To date, trials have focused on animal models. “These early tests have been very encouraging and we now need to take the next steps to bring this technique to a state where it can be administered to humans — hopefully in a few years’ time.”

Thanks to Slashdot reader Falconhell for sharing the article!

In a trial of 24 patients who received the therapy, 20 saw improvements or stability in their symptoms and no fatal or serious adverse effects were reported. Early brain scans suggest that some damaged nerve cells may have been “repaired” by the therapy in a process called remyelination, which could mean a reversal of damage caused by MS in the nervous system, but this has not yet been confirmed. While the results are extremely promising, it is an early Phase 1 trial with a small sample size and no placebo or control group, so it is unclear whether the results are significant at this stage. However, it is unlikely that this repair would occur naturally, suggesting the therapy is having a beneficial effect on some level.

In a study involving mice, the researchers found their bacteria “significantly” reduced the damage ampicillin did to the test subject’s gut microbes and allowed those communities to recover fully after just three days. By contrast, in mice that only received the antibiotic, the researchers saw a much greater loss of microbial diversity. “We are now focusing on getting these living therapies to patients and are finalizing the design of an effective, short, and inexpensive clinical trial,” said Andres Cubillos-Ruiz, the lead author of the study.

With depression, the brain can get stuck in a rut and locked into a particular negative way of thinking, he said. But when given psilocybin, people’s brains opened up and became “more flexible and fluid” up to three weeks later. This could be seen in increased connections between regions of the brain when patients were scanned. These patients were more likely to experience an improvement in mood months later. Similar changes were not seen in the brains of people treated with a standard antidepressant.

The results, published in Nature Medicine, are taken from two studies. In the first, everyone received psilocybin; and in the second — a randomized controlled trial – some were given the drug while others were given a different antidepressant. All participants also received talking therapies with registered mental health professionals. Brain scans were taken before, and then one day or three weeks after taking the therapy.

Many of the deaths occurred in people in the prime of their lives, Woolf says, and drove the overall U.S. life expectancy to fall to 76.6 years — the lowest in at least 25 years. “The motivation for this study was to determine whether the horrible drop in life expectancy that we documented in 2020 resolved or rebounded in 2021 or whether there was a continued decline. Unfortunately, we did not find good news,” Woolf told NPR in an interview.