Category: science

It’s possible that this prompted her immune system to produce antibodies against her baby’s blood — antibodies that then crossed the placenta and harmed her child, ultimately leading to its loss. It may seem implausible that such a thing could happen, but many decades ago, before doctors had a better understanding of blood groups, it was much more common. Through studying the mother’s blood sample, along with a number of others, scientists were able to unpick exactly what made her blood different, and in the process confirmed a new set of blood grouping — the “Er” system, the 44th to be described. You’re probably familiar with the four main blood types — A, B, O, and AB. But this isn’t the only blood classification system. There are many ways of grouping red blood cells based on differences in the sugars or proteins that coat their surface, known as antigens.

The grouping systems run concurrently, so your blood can be classified in each — it might, for instance, be type O in the ABO system, positive (rather than negative) under the Rhesus system, and so on. Thanks to differences in antigens, if someone receives incompatible blood from a donor, for example, the recipient’s immune system may detect those antigens as foreign and react against them. This can be highly dangerous, and is why donated blood needs to be a suitable match if someone is having a transfusion. On average, one new blood classification system has been described by researchers each year during the past decade. These newer systems tend to involve blood types that are mind-bogglingly rare but, for those touched by them, just knowing that they have such blood could be lifesaving. This is the story of how scientists unraveled the mystery of the latest blood system — and why it matters.

Using previously done research on salamanders, Lynne and colleagues at City University of New York and Princeton examined how the arrow of time is represented in interactions between the amphibians’ neurons in response to watching a movie. Their research is soon to be published in the journal Physical Review Letters. On one hand, it’s somewhat obvious that an arrow of time would be biologically produced. “To be alive, almost, you have to have an arrow of time because you develop from a baby to an adult, and you’re constantly moving and taking in stimuli,” Lynne said. Indeed, entropy here is irreversible — you cannot go back. What the team found was anything but intuitive, however.

Lynne and colleagues looked at a separate 2015 study where researchers had salamanders watch two different movies. One depicted a scene of fish swimming around, similar to what a salamander might experience in everyday life. As in the real world, the video had a clear arrow of time — that is, if you watched it in reverse, it would look different than if you played it forwards. The other video contained only a gray screen with a black, horizontal bar in the middle of the screen, which moved quickly up and down in a random, jittery way. This video didn’t have an obvious arrow of time. A major question for the researchers was if they could pick out signs of “local irreversibility” in interactions between small groups of retinal neurons in response to this stimulus. Would interactions with irreversibility — they would look different if played in reverse, having an “arrow of time” — present in simpler or more complex interactions between neurons? “You can go look at a system and you can ask: are the more complicated interactions strongly producing the arrow of time, or is it the simpler dynamics?” said Lynn.

The researchers found that the interactions between simple pairs of neurons primarily determined the arrow of time, no matter which movie the salamanders watched. In fact, the authors found a stronger arrow of time for the neurons when salamanders watched the video with the gray screen and black bar — in other words, the video without an arrow of time in its content elicited a greater arrow of time in the neurons. “We naively thought that if the stimulus has a stronger arrow of time, that would show up on your retina,” said Lynn. “But it was the opposite. So that’s why it was surprising to us.” While the researchers can’t say for sure why this is, Lynn said that it might be because salamanders are more used to seeing something like the fish movie, and processing the more artificial movie took greater energy. In a more disordered system, which would have a greater arrow of time, more energy is consumed. “Being alive will still define an arrow of time,” Lynne said, no matter the stimulus.

Although most psychedelics remain illegal under federal law, the Food and Drug Administration is weighing potential therapeutic uses for compounds like psilocybin, LSD and MDMA, the drug better known as Ecstasy. Dr. Michael Bogenschutz, director at NYU Langone Center for Psychedelic Medicine and the study’s lead investigator, said the findings offered hope for the nearly 15 million Americans who struggle with excessive drinking — roughly 5 percent of all adults. Excessive alcohol use kills an estimated 140,000 people each year.

In the current study, the team looked to level up the number of graphene layers. They fabricated two new structures, made from four and five graphene layers, respectively. Each structure is stacked alternately, similar to the shifted cheese sandwich of twisted trilayer graphene. The team kept the structures in a refrigerator below 1 kelvin (about -273 degrees Celsius), ran electrical current through each structure, and measured the output under various conditions, similar to tests for their bilayer and trilayer systems. Overall, they found that both four- and five-layer twisted graphene also exhibit robust superconductivity and a flat band. The structures also shared other similarities with their three-layer counterpart, such as their response under a magnetic field of varying strength, angle, and orientation.

These experiments showed that twisted graphene structures could be considered a new family, or class of common superconducting materials. The experiments also suggested there may be a black sheep in the family: The original twisted bilayer structure, while sharing key properties, also showed subtle differences from its siblings. For instance, the group’s previous experiments showed the structure’s superconductivity broke down under lower magnetic fields and was more uneven as the field rotated, compared to its multilayer siblings. The team carried out simulations of each structure type, seeking an explanation for the differences between family members. They concluded that the fact that twisted bilayer graphene’s superconductivity dies out under certain magnetic conditions is simply because all of its physical layers exist in a “nonmirrored” form within the structure. In other words, there are no two layers in the structure that are mirror opposites of each other, whereas graphene’s multilayer siblings exhibit some sort of mirror symmetry. These findings suggest that the mechanism driving electrons to flow in a robust superconductive state is the same across the twisted graphene family.

In this case, they arranged the carbon atoms into the shape of the organic compound polyacetylene, which is made up of a repeating chain of carbon and hydrogen atoms with an alternating pattern of single and double carbon bonds between them. To simulate those bonds, the team placed the carbon atoms at different distances apart. Next, the researchers ran an electrical current through the circuit to check whether it would match the signature of a natural polyacetylene molecule — and sure enough, it did. In other tests, the team created two different versions of the chain by cutting bonds at different places, and the resulting currents matched theoretical predictions perfectly. The significance of this new quantum circuit, the team says, is that it could be used to study more complicated molecules, which could eventually yield new materials, pharmaceuticals, or catalysts. This 10-atom version is right on the limit of what classical computers can simulate, so the team’s plans for a 20-atom quantum circuit would allow for simulation of more complex molecules for the first time. The research has been published in the journal Nature.

Thiomargarita magnifica, a bacteria discovered on sunken red mangrove leaves in Guadeloupe, Lesser Antilles, has blown this standard scale out of the water. The species has evolved filamentary cells that are “larger than all other known giant bacteria by ~50-fold,” making them “visible to the naked eye,” according to a study published on Thursday in Science.
Scientists led by Jean-Marie Volland, a marine biologist who holds joint appointments at the Laboratory for Research in Complex Systems and the Joint Genome Institute (JGI), a U.S. Department of Energy office at Lawrence Berkeley National Laboratory, suspect that this record-breaking adaptation is partly due to the astonishing number of duplicated genes wielded by T. magnifica, an ability that is known as polyploidy. […]

The results revealed that these bacteria contain DNA clusters in their cells, which are located in compartments bordered by membranes that the team called “pepins.” These organized pepins provide a stark contrast to the free-floating DNA seen in the cells of most bacteria. In addition, the team’s genetic sequencing revealed that T. magnifica contains hundreds of thousands of genome copies that are dispersed across the cell, adding up to about three times the number of genes in most bacteria, which is an extreme example of polyploidy. “These cellular features likely allow the organism to grow to an unusually large size and circumvent some of the biophysical and bioenergetic limitations on growth,” Volland and his colleagues said.

Atom lasers that scientists have managed to achieve to date have been of the pulsed, rather than continuous variety; and involve firing off just one pulse before a new BEC needs to be generated. In order to create a continuous BEC, a team of researchers at the University of Amsterdam in the Netherlands realized something needed to change. “In previous experiments, the gradual cooling of atoms was all done in one place. In our setup, we decided to spread the cooling steps not over time, but in space: we make the atoms move while they progress through consecutive cooling steps,” explained physicist Florian Schreck. “In the end, ultracold atoms arrive at the heart of the experiment, where they can be used to form coherent matter waves in a BEC. But while these atoms are being used, new atoms are already on their way to replenish the BEC. In this way, we can keep the process going — essentially forever.” The research has been published in the journal Nature.

The research paper includes a description of the technology called focused rotary jet spinning, a process by which the biopolymer is produced, and quantitative assessments showing the coating extended the shelf life of avocados by 50 percent. The coating can be rinsed off with water and degrades in soil within three days, according to the study. […] The paper describes how the new fibers encapsulating the food are laced with naturally occurring antimicrobial ingredients — thyme oil, citric acid and nisin. Researchers in the Demokritou research team can program such smart materials to act as sensors, activating and destroying bacterial strains to ensure food will arrive untainted. This will address growing concern over food-borne illnesses as well as lower the incidence of food spoilage […].

“Every pharmaceutical we produce at some point or another has a palladium-catalysed step in it,” says Per-Ola Norrby, a pharmaceutical researcher at drug giant AstraZeneca in Gothenburg, Sweden. Palladium-catalysed reactions are so valuable that, in 2010, their discoverers shared a Nobel prize. But despite its versatility, chemists are trying to move away from palladium. The metal is more expensive than gold, and molecules that contain palladium can also be extremely toxic to humans and wildlife. Chemical manufacturers have to separate out all traces of palladium from their products and carefully dispose of the hazardous waste, which adds extra expense. Thomas Fuchb, a medicinal chemist at the life-sciences company Merck in Darmstadt, Germany, gives the example of a reaction to make 3 kilograms of a drug molecule for which the ingredients cost US$250,000. The palladium catalyst alone adds $100,000; purifying it out of the product another $30,000.

Finding less-toxic alternatives to the metal could help to reduce environmental harm from palladium waste and move the chemicals industry towards ‘greener’ reactions, says Tianning Diao, an organometallic chemist at New York University. Researchers hope to swap palladium for more common metals, such as iron and nickel, or invent metal-free catalysts that sidestep the issue altogether. Several times in the past two decades, researchers have reported finding palladium-free catalysts. But in what has become a recurring pattern for the field, each heralded discovery turned out to be a mistake.

[…] Part of the challenge of preventing rip-related drownings stems from the lack of a simple method to escape them. Rip currents form when waves pile water near the shoreline. The water then gushes back out to sea, taking the path of least resistance. It might flow along channels carved in between sandbars or next to solid structures, such as jetties or rocky headlands. These types of rips can stick around year after year. Others are more erratic, creating fleeting bursts of seaward-flowing water on smooth, open beaches. People often mislabel rip currents as undertows or rip tides. Rip currents are not caused by tides, however, and undertows are a different, weaker current, formed when water pushed onto the beach moves back offshore along the seabed. Some telltale signs of a rip include a streak of churned-up, sandy water or a dark, flat gap between breaking waves.

It’s not surprising that rip currents are often misunderstood by the public because, for decades, beach-safety experts also had an oversimplified perception of their mechanics. In some of the earliest research on rips in the mid-20th century, American scientists watched sticks, pieces of kelp, and volleyballs float out to sea and described lanes of flowing water extending more than 300 meters offshore. This work formed the basis for the popular view of rip currents as jets flowing perpendicular to the beach, shooting out past the surf. To escape the river of current, experts recommended that bathers swim parallel to the beach — a message once broadcast through education campaigns and warning signs in the United States and Australia. As it turns out, that approach may not always work.