PFAS Increase Likelihood of Death By Cardiovascular Disease, Study Shows

New submitter berghem shares a report from The Guardian: For the first time, researchers have formally shown that exposure to toxic PFAS increases the likelihood of death by cardiovascular disease, adding a new level of concern to the controversial chemicals’ wide use. The findings are especially significant because proving an association with death by chemical exposure is difficult, but researchers were able to establish it by reviewing death records from northern Italy’s Veneto region, where many residents for decades drank water highly contaminated with PFAS, also called “forever chemicals.” Records further showed an increased likelihood of death from several cancers, but stopped short of establishing a formal association because of other factors. […]

Veneto’s drinking water was widely contaminated by a PFAS-production plant between 1985 and 2018. Researchers first found an excess of about 4,000 deaths during this period, or about one every three days. Part of the region was supplied with water from a different source, giving researchers the opportunity to compare records for tens of thousands of people who drank contaminated water and lived near those who did not. Though PFAS can affect the cardiovascular system in different ways, it is largely a problem because it produces stubbornly high and dangerous levels of cholesterol. The levels are difficult to control because they aren’t caused by dietary or lifestyle choices that can be addressed with adjustments, but hormonal changes that affect the metabolism and the body’s ability to control plaque in arteries. The study’s authors suspect that post-traumatic stress disorder caused by the environmental disaster, which upended lives across the region, may also be contributing to circulatory disease. The evidence of a jump in kidney cancer was also “very clear,” [said Annibale Biggeri, the peer-reviewed study’s lead author, and a researcher with the University of Padua]. In the study’s first five years, 16 cases were recorded, while 65 were recorded in the last five years. It also found elevated levels of testicular cancer during some time periods.

The records “showed clearly” that earlier life exposures led to higher levels of mortality, except for women who have multiple children. Previous research has found levels were higher in women with only one child. The chemicals accumulate in placentas and are passed on to children during pregnancy, which reduces levels in the body. Mortality levels among women who were of child-bearing age were generally lower, but increased in older women. The chemicals will be passed down to children for generations, said Laura Facciolo, a Veneto resident who drank contaminated water. She said the findings underscore the need to ban PFAS, and the disaster’s injustice. The findings have been published in the journal Environmental Health.

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Surgeons Perform UK’s First Operation Using Apple’s Vision Pro Headset

Surgeons in the United Kingdom have performed the first operation in the country using Apple’s Vision Pro headset. TechSpot reports: During a recent operation to repair a patient’s spine at the private Cromwell Hospital in London, a scrub nurse working alongside the surgeon used the Vision Pro to help prepare, keep track of the procedure, and choose the right tools, reports the Daily Mail. This marked the first operation in the UK where the Vision Pro was used. The software running on Apple’s headset during the operation comes from US company eXeX, which has made similar programs for Microsoft’s HoloLens. It offers nurses and technicians both holographic and touch-free access to the surgical setup and the procedural guides from within the sterile field of the operating room, according to the press release. The software also tracks each stage of an operation and can measure how well the op went compared to previous procedures performed by other surgeons.

“It eliminates human error and eliminates the guesswork,” said Suvi Verho, lead scrub nurse at London Independent Hospital. “It gives you confidence in surgery.” While this marked the first time that the Vision Pro was used during a UK surgery, the first-ever time the device was used in an operating room was last month, just three days after its release, when Orlando resident and world-renowned Neurosurgeon Dr. Robert Masson wore it during several spine reconstruction surgeries. “We are in a new era of surgery, and for the first time, our surgical teams have the brilliance of visual holographic guidance and maps, improving visuospatial and temporal orientation for each surgical team and for each surgery in all specialties,” said Masson.

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University of Alabama Pauses IVF Services After Court Embryo Ruling

Following a recent ruling from the state supreme court, the University of Alabama at Birmingham health system said it is pausing all in vitro fertilization (IVF) treatments for fear of criminal prosecution or punitive damages. On Friday, the Alabama Supreme Court ruled that frozen embryos are “children,” entitled to full personhood rights, and anyone who destroys them could be liable in a wrongful death case. The Hill reports: “We are saddened that this will impact our patients’ attempt to have a baby through IVF, but we must evaluate the potential that our patients and our physicians could be prosecuted criminally or face punitive damages for following the standard of care for IVF treatments,” the health system said. […] It is standard practice in IVF to fertilize several eggs and then transfer one into a woman’s uterus. Any remaining normally developing embryos can be, at the patient’s request and consent, frozen for later use. But legal experts say it’s unclear if the standard practice is illegal in Alabama and could make IVF virtually inaccessible in the state.

According to the American Society of Reproductive Medicine, the best-developing embryo will be transferred into a patient for an attempt at a pregnancy while the rest are frozen for later use, in case the first one does not develop into a live birth, or the patient later desires another child. According to the Centers for Disease Control and Prevention, approximately 238,126 patients underwent IVF treatment in 2021, resulting in the births of 97,128 babies, the last year for which statistics were available. There are 453 IVF clinics nationwide.

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Early Blood Test To Predict Dementia Is Step Closer As Biological Markets Identified

Researchers have made significant progress toward developing a blood test that can predict the risk of dementia up to 15 years before clinical diagnosis. The Guardian reports: Hopes for the test were raised after scientists discovered biological markers for the condition in blood samples collected from more than 50,000 healthy volunteers enrolled in the UK Biobank project. Analysis of the blood identified patterns of four proteins that predicted the onset of dementia in general, and Alzheimer’s disease and vascular dementia specifically, in older age. When combined with more conventional risk factors such as age, sex, education and genetic susceptibility, the protein profiles allowed researchers to predict dementia with an estimated 90% accuracy nearly 15 years before people received clinical confirmation of the disease.

For the latest study, blood samples from 52,645 UK adults without dementia were collected and frozen between 2006 and 2010 and analyzed 10 to 15 years later. More than 1,400 participants went on to develop dementia. Using artificial intelligence, the researchers looked for connections between nearly 1,500 blood proteins and developing dementia years later. Writing in Nature Aging, they describe how four proteins, Gfap, Nefl, Gdf15 and Ltbp2, were present in unusual levels among those who developed all-cause dementia, Alzheimer’s disease or vascular dementia. Higher levels of the proteins were warning signs of disease. Inflammation in the brain can trigger cells called astrocytes to over-produce Gfap, a known biomarker for Alzheimer’s. People with raised Gfap were more than twice as likely to develop dementia than those with lower levels.

Another blood protein, Nefl, is linked to nerve fibre damage, while higher than normal Gdf15 can occur after damage to the brain’s blood vessels. Rising levels of Gfap and Ltbp2 was highly specific for dementia rather than other brain diseases, the scientists found, with changes occurring at least 10 years before people received a dementia diagnosis. The researchers are speaking to companies to develop the test but said the cost, currently at several hundred pounds, would need to come down to make it viable.

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WHO Warns Against Using Artificial Sweeteners

The World Health Organization (WHO) on Monday released guidance on non-sugar sweeteners (NSS), recommending against using them to control body weight. From the report: The recommendation is based on the findings of a systematic review of the available evidence which suggests that use of NSS does not confer any long-term benefit in reducing body fat in adults or children. Results of the review also suggest that there may be potential undesirable effects from long-term use of NSS, such as an increased risk of type 2 diabetes, cardiovascular diseases, and mortality in adults. The recommendation applies to all people except individuals with pre-existing diabetes and includes all synthetic and naturally occurring or modified non-nutritive sweeteners that are not classified as sugars found in manufactured foods and beverages, or sold on their own to be added to foods and beverages by consumers. Common NSS include acesulfame K, aspartame, advantame, cyclamates, neotame, saccharin, sucralose, stevia and stevia derivatives.

The recommendation does not apply to personal care and hygiene products containing NSS, such as toothpaste, skin cream, and medications, or to low-calorie sugars and sugar alcohols (polyols), which are sugars or sugar derivatives containing calories and are therefore not considered NSS. “Replacing free sugars with NSS does not help with weight control in the long term. People need to consider other ways to reduce free sugars intake, such as consuming food with naturally occurring sugars, like fruit, or unsweetened food and beverages,” says Francesco Branca, WHO Director for Nutrition and Food Safety. “NSS are not essential dietary factors and have no nutritional value. People should reduce the sweetness of the diet altogether, starting early in life, to improve their health.”

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Sugar-Powered Implant Successfully Manages Type 1 Diabetes

Researchers have developed a novel fuel cell implant for type 1 diabetes that can successfully produce and release insulin when triggered. New Atlas reports: The fuel cell itself, which resembles a teabag that’s slightly larger than a fingernail, is covered in a nonwoven fabric and coated with alginate, an algae-derived product used widely in biomedicine because of its high degree of biocompatibility. When implanted under the skin, the cell’s alginate soaks up body fluid, allowing glucose to permeate the surface and flow into the power center. Inside the cell, the team developed a copper-based nanoparticle anode that splits glucose into gluconic acid and a proton to generate an electric current. “Many people, especially in the Western industrialized nations, consume more carbohydrates than they need in everyday life,” [Martin Fussenegger from the Department of Biosystems Science and Engineering at ETH Zurich] said. “This gave us the idea of using this excess metabolic energy to produce electricity to power biomedical devices.

The fuel cell was then coupled with an insulin capsule featuring the team’s beta cells, which could be triggered to secrete insulin via electric current from the implant. Overall, the two components provide a self-regulating circuit. When the fuel cell powered by glucose senses excess blood sugar, it powers up. This then stimulates the beta cells to produce and secrete insulin. As blood sugar levels dip, it trips a threshold sensor in the fuel cell, so it powers down, in turn stopping the insulin production and release. This self-sustained circuit could also produce enough power to communicate with a device such as a smartphone, which allows for monitoring and adjusting, and even has potential for remote access for medical intervention. The study was published in the journal Advanced Materials.

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America’s CDC Warns of Increase in Drug-Resistant Bacteria Infections

America’s Centers for Disease Control and Prevention “has issued a health advisory to warn the public of an increase of a drug-resistant bacteria called Shigella,” reports CNN:

There are limited antimicrobial treatments available for these particular drug-resistant strains of Shigella and it’s also easily transmissible, warned the CDC in the Friday advisory. It’s also able to spread antimicrobial resistance genes to other bacteria that infect the intestines…. The CDC says patients will recover from shigellosis without any antimicrobial treatment and it can be managed with oral hydration, but for those who are infected with the drug-resistant strains there are no recommendations for treatment if symptoms become more severe. The percentage of infections from drug-resistant strains of the bacteria increased from zero in 2015 to 5% in 2022, according to the CDC.

Nationwide, there are nearly 3 million antimicrobial-resistant infections each year, and more than 35,000 people die as a result, according to the CDC. A recent report by the United Nations said roughly 5 million deaths worldwide were associated with antimicrobial resistance in 2019 and the annual toll is expected to increase to 10 million by 2050 if steps are not taken to stop the spread of antimicrobial resistance.

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Apple Is Reportedly Closer To Bringing No-Prick Glucose Monitoring To the Watch

According to Bloomberg, Apple’s quest to bring blood glucose monitoring to the Apple Watch is now at a “proof-of-concept stage.” The last remaining hurdle is for it to be made smaller. Engadget reports: The technology, which uses lasers to gauge glucose concentration under the skin, was previously tabletop sized but has reportedly advanced to the point where an iPhone-sized wearable prototype is in the works. The system would not only help people with diabetes monitor their conditions, but would ideally alert people who are prediabetic, the insiders say. They could then make changes that prevent Type 2 (adult onset) diabetes.

The project has supposedly been in development for a long time. It began in 2010, when an ailing Steve Jobs had his company buy blood glucose monitoring startup RareLight. Apple is said to have kept the effort secret by operating it as a seemingly isolated firm, Avolonte Health, but folded it into a previously unknown Exploratory Design Group (XDG). CEO Tim Cook, Apple Watch hardware lead Eugene Kim and other top leaders have been involved.

Any real-world product is likely years away, according to Bloomberg. The industry also doesn’t have a great track record of bringing no-prick monitors to market. In 2018, Alphabet’s health subsidiary Verily scrapped plans for a smart contact lens that would have tracked glucose using tears. Even major brands with vast resources aren’t guaranteed success, in other words, and it’s not clear how accurate Apple’s solution would be.

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Amazon Closes $3.9 Billion Deal To Acquire One Medical

An anonymous reader quotes a report from CNBC: Amazon on Wednesday said it had closed its $3.9 billion deal for primary care provider One Medical. Amazon agreed last July to acquire One Medical to deepen its presence in health care, and “dramatically improve” the experience of getting medical care. Amazon has long had ambitions to expand into health care, buying online pharmacy PillPack in 2018 for $750 million, then launching its own virtual clinic for chronic conditions, and prescription perks for Prime members. The deal gives Amazon access to One Medical’s more than 200 brick-and-mortar medical offices in 26 markets, and roughly 815,000 members.

The purchase was the first major deal announced since CEO Andy Jassy took the helm from founder Jeff Bezos in July 2021, and Jassy has indicated he sees health care as a major area of expansion. In a statement, he said health care is ripe for disruption, citing long appointment times and the complexities of primary care. “Customers want and deserve better, and that’s what One Medical has been working and innovating on for more than a decade,” Jassy said in a statement. “Together, we believe we can make the health care experience easier, faster, more personal, and more convenient for everyone.” Amazon said it would discount One Medical memberships for U.S. users to $144 from $199 for the first year, regardless of whether they’re a Prime subscriber.

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Maryland Motor Vehicles Agency Wants To Know About Your Sleep Apnea

“Man goes to the doctor for a sleep apnea diagnosis, a few months later he gets a letter from the state of Maryland about his sleep apnea — and they won’t tell him how they found out about it,” writes Slashdot reader schwit1. NBC4 Washington reports: Dr. David Allick, a dentist in Rockville, was diagnosed with mild sleep apnea in June 2022. Months later, he received a letter from the MVA requesting additional information about his diagnosis in order “to determine your fitness to drive.” The September 2022 letter noted failure to return the required forms, which included a report from his physician, could result in the suspension of his license. Allick said he isn’t clear how the state learned about his medical diagnosis. But more importantly, he said he was previously unaware of a little-known Maryland law requiring people to report their sleep apnea diagnosis to state driving authorities. Allick said he still has questions about what prompted the ordeal. “Everybody I talked to — nobody’s heard of anything like this,” he said, also acknowledging: “I’m sure they want to keep the roads safe.” schwit1 adds: “How is this not a HIPAA violation?”

The investigation team at NBC4 Washington found that Allick is one of 1,310 people whose sleep apnea diagnoses “have led to medical reviews by the Maryland MVA.” The state department didn’t have data on how many of these Maryland drivers have had their license suspended.

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