An Eye Implant Engineered From Proteins In Pigskin Restored Sight In 14 Blind People

According to a new study published in the journal Nature Biotechnology, researchers implanted corneas made from pig collagen to restore sight in 20 people who were blind or visually impaired. “Fourteen of the patients were blind before they received the implant, but two years after the procedure, they had regained some or all of their vision,” notes NBC News. “Three had perfect vision after the surgery.” From the report: The patients, in Iran and India, all suffered from keratoconus, a condition in which the protective outer layer of the eye progressively thins and bulges outward. “We were surprised with the degree of vision improvement,” said Neil Lagali, a professor of experimental ophthalmology at Linkoping University in Sweden who co-authored the study. Not all patients experienced the same degree of improvement, however. The 12 Iranian patients wound up with an average visual acuity of 20/58 with glasses; functional vision is defined as 20/40 or better with lenses. Nonetheless, Dr. Marian Macsai, a clinical professor of ophthalmology at the University of Chicago who wasn’t involved in the study, said the technology could be a game changer for those with keratoconus, which affects roughly 50 to 200 out of every 100,000 people. It might also have applications for other forms of corneal disease.

To create the implant, Lagali and his team dissolved pig tissue to form a purified collagen solution. That was used to engineer a hydrogel that mimics the human cornea. Surgeons then made an incision in a patient’s cornea for the hydrogel. “We insert our material into this pocket to thicken the cornea and to reshape it so that it can restore the cornea’s function,” Lagali said. Traditionally, human tissue is required for cornea transplants. But it’s in short supply, because people must volunteer to donate it after they die. So, Lagali said, his team was looking for a low-cost, widely available substitute. “Collagen from pigskin is a byproduct from the food industry,” he said. “This makes it broadly available and easier to procure.” After two years, the patients’ bodies hadn’t rejected the implants, and they didn’t have any inflammation or scarring.

But any experimental medical procedure comes with risk. In this case, Soiberman said, a foreign molecule like collagen could induce an immune reaction. The researchers prescribed patients an eight-week course of immunosuppressive eyedrops to lower the risk, which is less than the amount given to people who receive cornea transplants from human tissue. In those cases, patients take immunosuppressive medicine for more than a year, Lagali said. “There’s always a risk for rejection of the human donor tissue because it contains foreign cells,” he said. “Our implant does not contain any cells … so there’s a minimal risk of rejection.” The procedure itself was also quicker than traditional cornea transplants. The researchers said each operation took about 30 minutes, whereas transplants of human tissue can take a couple of hours. […] It’s not yet clear whether the surgery would work for patients who have other forms of corneal disease aside from keratoconus.

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Thieves Stole $23 Million in One of the Largest YouTube Royalties Scams Ever

“Need an easy way to make $23 million?” asks Mashable.
“Have you ever considered just claiming music others uploaded to YouTube as your own and collecting the royalties?

That’s basically all two Phoenix men did to swindle Latin music artists like Daddy Yankee and Julio Iglesias out of millions of dollars in royalties, as detailed in a new piece from Billboard last week.

According to Kristin Robinson of Billboard, Jose “Chenel” Medina Teran and Webster Batista set up a media company called MediaMuv and claimed to own the rights to various Latin music songs and compositions. In total, MediaMuv claimed to own more than 50,000 copyrights since 2017, when Teran and Batista began their scheme.

In order for MediaMuv to claim these copyrights and collect royalties through YouTube’s Content ID system, the fraudulent company needed to partner with AdRev, a third-party company that has access to YouTube’s CMS and Content ID tools and helps artists manage their digital copyrights. MediaMuv created a few fake documents and provided AdRev with this paperwork in order to prove ownership over the music it claimed. From there, AdRev not only helped MediaMuv collect royalties for those copyrights but also provided Terana and Batista with direct access to YouTube’s CMS so they could claim copyrights on its own.

Teran and Batista’s four-year-long royalties heist came to an end late last year following an investigation from the IRS. According to Billboard, the two were indicted on “30 counts of conspiracy, wire fraud, money laundering and aggravated identity theft.”

Mashable calls it “a huge reminder that online copyright is deeply flawed…”

“[J]ust think about how many more careful scammers are still skimming royalties off of an untold number of artists.”

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Rust 1.63 Released, Adding Scoped Threads

This week the Rust team announced the release of Rust 1.63.

One noteable update? Adding scoped threads to the standard library:

Rust code could launch new threads with std::thread::spawn since 1.0, but this function bounds its closure with ‘static. Roughly, this means that threads currently must have ownership of any arguments passed into their closure; you can’t pass borrowed data into a thread. In cases where the threads are expected to exit by the end of the function (by being join()’d), this isn’t strictly necessary and can require workarounds like placing the data in an Arc.

Now, with 1.63.0, the standard library is adding scoped threads, which allow spawning a thread borrowing from the local stack frame. The std::thread::scope API provides the necessary guarantee that any spawned threads will have exited prior to itself returning, which allows for safely borrowing data.
The official Rust RFC book says “The main drawback is that scoped threads make the standard library a little bit bigger,” but calls it “a very common and useful utility…great for learning, testing, and exploratory programming.

“Every person learning Rust will at some point encounter interaction of borrowing and threads. There’s a very important lesson to be taught that threads can in fact borrow local variables, but the standard library [didn’t] reflect this.” And otherwise, “Implementing scoped threads is very tricky to get right so it’s good to have a reliable solution provided by the standard library.”

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Researchers: It’s ‘Unlikely’ There’s Water- or Ice-Saturated Layers Below InSight Mars Lander

Did Mars ever support life? One clue might be quantifying just how much ice (and other minerals) are lurking just below the planet’s surface, a team of researchers argued this month. “If life exists on Mars, that is where it would be,” they said in a news release this week. “There is no liquid water on the surface,” but in a contrary scenario, “subsurface life would be protected from radiation.”

Locating ice and minerals has another benefit too, they write in the journal Geophysical Research Letters: to “prepare for human exploration.” And fortunately, there’s a tool on the InSight lander (which touched down in 2018) that can help estimate the velocity of seismic waves inside the geological crust of Mars — velocities which change depending on which rock types are present, and which materials are filling pores within rocks (which could be ice, water, gas, or other mineral cements).

That’s the good news. But after running computer models of applied rock physics thousands and thousands of times, the researchers believe it’s unlikely that there’s any layers saturated with water (or ice) in the top 300 meters (1,000 feet) of the crust of Mars. “Model results confirm that the upper 300 meters of Mars beneath InSight is most likely composed of sediments and fractured basalts.”

The researchers reached a discouraging conclusion, reports Space.com “The chances of finding Martian life appear poor at in the vicinity of NASA’s InSight lander.”
The subsurface around the landing zone — an equatorial site chosen especially for its flat terrain and good marsquake potential — appears loose and porous, with few ice grains in between gaps in the crust, researchers said…. The equatorial region where InSight is working, in theory, should be able to host subsurface water, as conditions are cold enough even there for water to freeze. But the new finding is challenging scientists’ assumptions about possible ice or liquid water beneath the subsurface near InSight, whose job is to probe beneath the surface.

While images from the surface have suggested there might be sedimentary rock and lava flows beneath InSight, researchers’ models have uncertainties about porosity and mineral content. InSight is helping to fill in some of those gaps, and its new data suggests that “uncemented material” largely fills in the region blow the lander. That suggests little water is present, although more data needs to be collected.

It’s unclear how representative the InSight data is of the Martian subsurface in general, but more information may come courtesy of future missions. NASA is considering a Mars Life Explorer that would drill 6 feet (2 meters) below the surface to search for possible habitable conditions. Additionally, a proposed Mars Ice Mapper Mission could search for possible water reservoirs for human missions.

And of course, as the researchers point out in their announcement, “big ice sheets and frozen ground ice remain at the Martian poles.”

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Nuclear Fusion Breakthrough Confirmed: California Team Achieved Ignition. Research Continues

“A major breakthrough in nuclear fusion has been confirmed a year after it was achieved at a laboratory in California,” reports Newsweek:

Researchers at Lawrence Livermore National Laboratory’s National Ignition Facility (NIF) recorded the first case of ignition on August 8, 2021, the results of which have now been published in three peer-reviewed papers….

Ignition during a fusion reaction essentially means that the reaction itself produced enough energy to be self-sustaining, which would be necessary in the use of fusion to generate electricity. If we could harness this reaction to generate electricity, it would be one of the most efficient and least polluting sources of energy possible. No fossil fuels would be required as the only fuel would be hydrogen, and the only by-product would be helium, which we use in industry and are actually in short supply of….

This landmark result comes after years of research and thousands of man hours dedicated to improving and perfecting the process: over 1,000 authors are included in the Physical Review Letters paper.

This week the laboratory said that breakthrough now puts researchers “at the threshold of fusion gain and achieving scientific ignition,” with the program’s chief scientist calling it “a major scientific advance in fusion research, which establishes that fusion ignition in the lab is possible at the National Ignition Facility.”

More news from this week’s announcement by the Lawrence Livermore National Laboratory:
Since the experiment last August, the team has been executing a series of experiments to attempt to repeat the performance and to understand the experimental sensitivities in this new regime. “Many variables can impact each experiment,” Kritcher said. “The 192 laser beams do not perform exactly the same from shot to shot, the quality of targets varies and the ice layer grows at differing roughness on each target….”

While the repeat attempts have not reached the same level of fusion yield as the August 2021 experiment, all of them demonstrated capsule gain greater than unity with yields in the 430-700 kJ range, significantly higher than the previous highest yield of 170 kJ from February 2021. The data gained from these and other experiments are providing crucial clues as to what went right and what changes are needed in order to repeat that experiment and exceed its performance in the future. The team also is utilizing the experimental data to further understanding of the fundamental processes of fusion ignition and burn and to enhance simulation tools in support of stockpile stewardship.

Looking ahead, the team is working to leverage the accumulated experimental data and simulations to move toward a more robust regime — further beyond the ignition cliff — where general trends found in this new experimental regime can be better separated from variability in targets and laser performance. Efforts to increase fusion performance and robustness are underway via improvements to the laser, improvements to the targets and modifications to the design that further improve energy delivery to the hotspot while maintaining or even increasing the hot-spot pressure. This includes improving the compression of the fusion fuel, increasing the amount of fuel and other avenues.

“It is extremely exciting to have an ‘existence proof’ of ignition in the lab,” said Omar Hurricane, chief scientist for the lab’s inertial confinement fusion program. “We’re operating in a regime that no researchers have accessed since the end of nuclear testing, and it’s an incredible opportunity to expand our knowledge as we continue to make progress.”
Thanks to long-time Slashdot reader hesdeadjim99 for sharing the news.

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Ransomware Causes ‘Major’, Long-Lasting Outage for UK Health Service’s Patient Notes

The Independent reports that the UK’s National Health System is experiencing a major outage “expected to last for more than three weeks” after a third-party supplying the NHS’s “CareNotes” software was hit by ransomware.

Unfortunately, this leaves doctors unable to see their notes on patients, and the mental health trusts that provide care “across the country will be left unable to access patient notes for weeks, and possibly months.”

Oxford Health NHS Foundation Trust has declared a critical incident over the outage, which is believed to affect dozens of trusts, and has told staff it is putting emergency plans in place. One NHS trust chief said the situation could possibly last for “months” with several mental health trusts, and there was concern among leaders that the problem is not being prioritised.

In an email to staff, Oxford Health NHS Foundation Trust chief executive Nick Broughton, said: “The cyberattack targeted systems used to refer patients for care, including ambulances being dispatched, out of hours appointment bookings, triage, out of hours care, emergency prescriptions and safety alerts. It also targeted the finance system used by the trust…. An NHS director said: “The whole thing is down. It’s really alarming…we’re carrying a lot of risk as a result of it because you can’t get records and details of assessments, prescribing, key observations, medical mental health act observations. You can’t see any of it…Staff are going to have to write everything down and input it later.”

They added: “There is increased risk to patients. We’re finding it hard to discharge people, for example to housing providers, because we can’t access records.”

“‘Weeks’ is an unreasonable period,” argues Slashdot reader Bruce66423, wondering why it couldn’t be resolved with a seemingly simple restore from backups?

And Alan Woodward, a professor of cybersecurity at Surrey University, warns the Guardian that “Even if it was ransomware … that doesn’t mean data was not stolen.”

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Are Space Scientists Ready For Starship – the Biggest Rocket Ever?

Slashdot reader sciencehabit shared this thought-provoking anecdote from Science magazine:

NASA’s Lunar Crater Observation and Sensing Satellite mission was brutish and short. It began on 9 October 2009, when the hull of a spent Centaur rocket stage smashed into Cabeus crater, near the south pole of the Moon, with the force of about 2 tons of TNT. And it ended minutes later, when a trailing spacecraft flew through and analyzed the lofted plume of debris before it, too, crashed. About 6% of the plume was water, presumably from ice trapped in the shadowed depths of the crater, where the temperature never rises above -173ÂC. The Moon, it turned out, wasn’t as bone dry as the Apollo astronauts believed. “That was our first ground truth that there is water ice,” says Jennifer Heldmann, a planetary scientist at NASA’s Ames Research Center who worked on the mission.

Today, Heldmann wants to send another rocket to probe lunar ice — but not on a one-way trip. She has her eye on Starship, a behemoth under development by private rocket company SpaceX that would be the largest flying object the world has ever seen. With Starship, Heldmann could send 100 tons to the Moon, more than twice the lunar payload of the Saturn V, the workhorse of the Apollo missions. She dreams of delivering robotic excavators and drills and retrieving ice in freezers onboard Starship, which could return to Earth with tens of tons of cargo. By analyzing characteristics such as the ice’s isotopic composition and its depth, she could learn about its origin: how much of it came from a bombardment of comets and asteroids billions of years ago versus slow, steady implantation by the solar wind. She could also find out where the ice is abundant and pure enough to support human outposts. “It’s high-priority science, and it’s also critical for exploration,” Heldmann says.

When SpaceX CEO Elon Musk talks up Starship, it’s mostly about human exploration: Set up bases on Mars and make humans a multiplanetary species! Save civilization from extinction! But Heldmann and many others believe the heavy lifter could also radically change the way space scientists work. They could fly bigger and heavier instruments more often — and much more cheaply, if SpaceX’s projections of cargo launch costs as low as $10 per kilogram are to be believed. On Mars, they could deploy rovers not as one-offs, but in herds. Space telescopes could grow, and fleets of satellites in low-Earth orbit could become commonplace. Astronomy, planetary science, and Earth observation could all boldly go, better than they ever have before.

Of course, Starship isn’t real yet. All eyes will be on a first orbital launch test, expected sometime in the coming months.
Starship would’ve made it easier to deploy the massive James Webb Space Telescope, the article points out, while in the future Starship’s extra fuel capacity could make it easier to explore Mercury, earth’s outermost planets, and even interstellar space. In fact, Heldmann and colleagues have now suggested that NASA create a dedicated funding line for missions relying on Starship. Heldmann argues that “We on the science side need to be ready to take advantage of those capabilities when they come online.”

The article notes that at an event in February, Elon Musk “explained how a single Starship, launching three times per week, would loft more than 15,000 tons to orbit in a year — about as much as all the cargo that has been lifted in the entire history of spaceflight.”

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Baidu Has China’s First Permits For Fully Driverless Robotaxi Services

China’s first fully autonomous, commercial robotaxi rides — with no safety drivers — are about to open for public passengers in Wuhan and Chongqing, marking an inflection point for one of the key technological revolutions of the 21st century. New Atlas reports: The two newly-issued permits allow Baidu to charge for driverless rides within a 13-sq-km (5-sq-mi) area in Wuhan, between 9 am and 5 pm, and within a larger 30-sq-km (11.6-sq-mi) zone in Chonqing’s Yongchuan district between 9.30 am and 5.30 pm — so while they’re currently set to avoid peak hours, they’ll be mixing it up with plenty of daytime traffic. Each zone will run five 5th-generation Apollo cars, with remote drivers ready to assume control if the vehicles get themselves into any sticky situations. Home base will be watching closely through the cars’ camera systems, particularly in these early days.

Baidu’s Apollo Go is already the world’s biggest robotaxi company, with operations already live in all tier-one Chinese cities using the same 5th-gen car, with backup drivers on board. The company recently revealed its 6th-gen design, its first ground-up fully autonomous car for mass production. The Apollo RT6 will cost just RMB 250,000 (US$37,000) to manufacture, says Baidu, and its optional, removable steering wheel and generous, configurable cabin space will make it one of the first proper mobility pod-type services when it hits the streets commercially in 2023.

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NetBSD 9.3: A 2022 OS That Can Run On Late-1980s Hardware

Version 9.3 of NetBSD is here, able to run on very low-end systems and with that authentic early-1990s experience. The Register reports: Version 9.3 comes some 15 months after NetBSD 9.2 and boasts new and updated drivers, improved hardware support, including for some recent AMD and Intel processors, and better handling of suspend and resume. The next sentence in the release announcement, though, might give some readers pause: “Support for wsfb-based X11 servers on the Commodore Amiga.” This is your clue that we are in a rather different territory from run-of-the-mill PC operating systems here. A notable improvement in NetBSD 9.3 is being able to run a graphical desktop on an Amiga. This is a 2022 operating system that can run on late-1980s hardware, and there are not many of those around.

NetBSD supports eight “tier I” architectures: 32-bit and 64-bit x86 and Arm, plus MIPS, PowerPC, Sun UltraSPARC, and the Xen hypervisor. Alongside those, there are no less than 49 “tier II” supported architectures, which are not as complete and not everything works — although almost all of them are on version 9.3 except for the version for original Acorn computers with 32-bit Arm CPUs, which is still only on NetBSD 8.1. There’s also a “tier III” for ports which are on “life support” so there may be a risk Archimedes support could drop to that. This is an OS that can run on 680×0 hardware, DEC VAX minicomputers and workstations, and Sun 2, 3, and 32-bit SPARC boxes. In other words, it reaches back as far as some 1970s hardware. Let this govern your expectations. For instance, in VirtualBox, if you tell it you want to create a NetBSD guest, it disables SMP support.

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