Psilocybin Has No Short- Or Long-Term Detrimental Effects In Healthy People

New research from the Institute of Psychiatry, Psychology, & Neuroscience (IoPPN) at King’s College London, in partnership with COMPASS Pathways, has established that psilocybin can be safely administered at doses of either 10mg or 25mg to up to six participants simultaneously. King’s College London reports: The research, published in The Journal of Psychopharmacology, is an essential first step in demonstrating the safety and feasibility of psilocybin — a psychedelic drug isolated from the Psilocybe mushroom — for use within controlled settings alongside talking therapy as a potential treatment for a range of mental health conditions, including treatment-resistant depression (TRD) and PTSD. Current treatment options for these conditions are ineffective or partially effective for many people, resulting in a significant unmet need. Early research has indicated a potential for psilocybin therapy to treat these groups, but no trials have been undertaken at the scale needed for regulatory approval to make the therapy available.

The trial is the first of its kind to thoroughly investigate the simultaneous administration of psilocybin. 89 healthy participants with no recent (within 1 year) use of psilocybin were recruited. 60 individuals were randomly picked to receive either a 10mg or 25mg dose of psilocybin in a controlled environment. In addition, all participants were provided with one-to-one support from trained psychotherapists. The remaining 29 participants acted as the control group and received a placebo, also with psychological support. Participants were closely monitored for six to eight hours following administration of psilocybin and then followed up for 12 weeks. During this time, they were assessed for a number of possible changes, including sustained attention, memory, and planning, as well as their ability to process emotions. Throughout the study, there were no instances of anyone withdrawing from the study due to an adverse event, and no consistent trends to suggest that either of the psilocybin doses had any short- or long-term detrimental effects on participants.

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A Record 4.5 Million Americans Quit Their Jobs In November

An anonymous reader quotes a report from Bloomberg: A record 4.5 million Americans quit their jobs in November while openings remained elevated, highlighting persistent churn in the labor market. The increase in departures was broad across industries and pushed the quits rate up to 3%, matching the most in data back to 2000. Meanwhile, the number of available positions fell to 10.6 million from an upwardly revised 11.1 million in October, the Labor Department’s Job Openings and Labor Turnover Survey, or JOLTS, showed Tuesday.

The median forecast in a Bloomberg survey of economists called for a rise to 11.1 million job openings. While the drop was the largest since April 2020, vacancies remain well above pre-pandemic levels. The unprecedented level of quits — including a record 1 million in leisure and hospitality alone — suggests a lingering struggle for employers to retain talent. Meanwhile, the month’s increase in hiring showed companies were able to make at least some headway filling vacancies. The data come ahead of Friday’s monthly employment report from the Labor Department, which is currently forecast to show that the U.S. added 420,000 jobs in December. […] Total hires were little changed in November at 6.7 million. Layoffs and discharges were also steady.

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Theranos Founder Elizabeth Holmes Found Guilty

After deliberating for more than 40 hours over six days, jurors in the Elizabeth Holmes criminal trial have found Holmes guilty on four of 11 charges of defrauding the company’s investors and patients. She was found not guilty on four counts. NPR reports: When the verdict was read, Holmes had no visible reaction. She sat masked in the courtroom and later hugged members of her family in the front row of the court. Holmes could face up to 20 years in prison, although legal experts say her sentence is likely to be less than that. During the nearly four-month federal trial in San Jose, jurors heard from over 30 witnesses called by prosecutors. Together, they painted Holmes as a charismatic entrepreneur who secured hundreds of millions of dollars in investment for a medical device that never delivered on her promises. When Theranos’ technology fell short, the government argued, Holmes covered it up and kept insisting that the machines would transform how diseases are diagnosed through blood tests. The jury’s decision followed seven days of deliberations. Still, the jury could not reach a unanimous decision on three charges, which will be resolved at a later date..

Holmes took the witness stand for more than 20 hours to defend herself. She accused her ex-boyfriend and former deputy at Theranos, Ramesh “Sunny” Balwani, of sexual abuse, saying that clouded her sense of judgement. Balwani faces a separate fraud trial in the same court in February. Holmes also showed remorse on the stand. She said she wished she had handled some key business matters differently. But she blamed others for the downfall of Theranos. She said lab directors whom she had trusted were the ones closest to the technology. And she said Balwani, not her, oversaw the company’s financial forecasts, which were later discovered to be grossly inflated. Yet the government offered evidence that Holmes had an iron grip on Theranos’ operations. Prosecutors argued she did not stop — and even helped spread — falsehoods about the company that misled investors into pouring millions into the startup. Theranos’ value, once estimated at more than $9 billion, was ultimately squandered.

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Chinese Fusion Reactor Maintains 70 Million Degrees Celsius For More Than 17 Minutes

Bowie Estate Sells Songwriting Catalog to Warner Music

David Bowie’s estate has sold his entire songwriting catalog to Warner Music, including classics like “Space Oddity,” “Let’s Dance” and “Heroes,” in the latest blockbuster deal for music rights. The New York Times reports: Warner’s music publishing division, Warner Chappell, announced the agreement on Monday, saying that it encompassed Bowie’s entire corpus as a songwriter, from the material on his 1967 debut album, “David Bowie,” to his final album, “Blackstar,” released just before Bowie’s death in 2016 at age 69. The deal, for more than 400 songs, also includes soundtrack music; the material for Bowie’s short-lived band Tin Machine from the late 1980s and early ’90s; and other works. The price of the transaction was not disclosed, but is estimated at about $250 million. “These are not only extraordinary songs, but milestones that have changed the course of modern music forever,” Guy Moot, the chief executive of Warner Chappell, said in a statement. David Bowie, the so-called “most wired rock star on the planet,” has been featured in a number of Slashdot stories over the years.

In 2002, Bowie talked about his new album, distribution deal with Sony, and how he’s “fully confident that copyright, for instance, will no longer exist in 10 years, and authorship and intellectual property is in for such a bashing.”

In the late 90s, Bowie advocated for MP3s, telling The Guardian that they “could change the entire idea of what music is — and that isn’t so bad.” Years later, he seemed to agree that concert ticket prices needed to increase to offset the rise in P2P file sharing and illegal downloads.

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‘Year 2022’ Bug Breaks Email Delivery For Microsoft Exchange On-Premise Servers

Kalper (Slashdot reader #57,281) shares news from Bleeping Computer:

Microsoft Exchange on-premise servers cannot deliver email starting on January 1st, 2022, due to a “Year 2022” bug in the FIP-FS anti-malware scanning engine.

Starting with Exchange Server 2013, Microsoft enabled the FIP-FS anti-spam and anti-malware scanning engine by default to protect users from malicious email. According to numerous reports from Microsoft Exchange admins worldwide, a bug in the FIP-FS engine is blocking email delivery with on-premise servers starting at midnight on January 1st, 2022.

Security researcher and Exchange admin Joseph Roosen said that this is caused by Microsoft using a signed int32 variable to store the value of a date, which has a maximum value of 2,147,483,647. However, dates in 2022 have a minimum value of 2,201,010,001 or larger, which is greater than the maximum value that can be stored in the signed int32 variable, causing the scanning engine to fail and not release mail for delivery. When this bug is triggered, an 1106 error will appear in the Exchange Server’s Event Log stating, “The FIP-FS Scan Process failed initialization. Error: 0x8004005. Error Details: Unspecified Error” or “Error Code: 0x80004005. Error Description: Can’t convert “2201010001” to long.” Microsoft will need to release an Exchange Server update that uses a larger variable to hold the date to officially fix this bug.

However, for on-premise Exchange Servers currently affected, admins have found that you can disable the FIP-FS scanning engine to allow email to start delivering again… Unfortunately, with this unofficial fix, delivered mail will no longer be scanned by Microsoft’s scanning engine, leading to more malicious emails and spam getting through to users.

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China Speeds Up Moon Base Plan in Space Race Against America

“China has formally approved three missions targeting the south pole of the moon, with the first to launch around 2024…” reports Space.com, “each with different goals and an array of spacecraft.”

The trio make up the so-called fourth phase for the Chinese lunar exploration program, which most recently landed on the moon last December with a sample-return mission dubbed Chang’e 5. Wu Yanhua, deputy head of the China National Space Administration (CNSA), told China Central Television (CCTV) in a recent interview that the three missions had been approved.

Chang’e 7 will be the first to launch; Wu did not provide a timeline, but previous reporting indicates a hoped-for launch around 2024, with the mission to include an orbiter, a relay satellite, a lander, a rover and a “mini flying craft” designed to seek out evidence of ice at the lunar south pole. The various component spacecraft will carry a range of science instruments including cameras, a radar instrument, an infrared spectrum mineral imager, a thermometer, a seismograph and a water-molecule analyzer; the mission will tackle goals including remote sensing, identifying resources and conducting a comprehensive study of the lunar environment…

Chang’e 8 will launch later this decade and will be a step toward establishing a joint International Lunar Research Station (ILRS) with Russia and potentially other partners. The mission is expected to test technology for using local resources and manufacturing with 3D printing, according to earlier Chinese press statements…. The ILRS plan includes development of a robotic base which can be later expanded to allow astronauts to make long-term stays on the lunar surface in the 2030s.
China had previously scheduled their lunar research station for the year 2035, reports the South China Morning Post. The newspaper cites concerns from Zhang Chongfeng, deputy chief designer of China’s manned space programme, that America’s space program might ultimately seize common land on the moon.
The US government and Nasa have proposed the Artemis Accords to set rules for future lunar activities. Already signed by more than a dozen US allies, the accords allow governments or private companies to protect their facilities or “heritage sites” by setting up safety zones that forbid the entry of others. China and Russia are opposed to the accords because this challenges the existing international protocols including the UN’s Moon Agreement, which states that the moon belongs to the entire human race, not a certain party, according to Zhang.

But to effectively counter the US on the moon, China would have to “take some forward-looking measures and deploy them ahead of schedule”, he said in a paper published in domestic peer-reviewed journal Aerospace Shanghai in June… Instead of building an orbiting “gateway”, China would directly put a nuclear-powered research station on the moon. The unmanned facility would allow visiting Chinese astronauts to stay on the moon for as long as their American peers but only at a fraction of the cost. To counter the US territorial claims, China would also deploy a mobile station. This moon base on wheels would be able to roam freely on the lunar surface for over 1,000km, and the use of artificial intelligence technology would mean astronauts need not be present for its operation.

And, unlike the American programme, which focuses on surface activities, China would pay a great deal of attention to the exploration of caves, which could provide a natural shelter for the construction of permanent settlements.

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17-Year-Old Beats Magnus Carlsen in World Rapid Chess Championship

Each player gets 15 minutes for all moves (plus a 10-second-per-move increment) at the World Rapid Chess Championship.

But players only get three minutes for all moves (plus a 2-second-per-move increment) in the World Blitz Chess Championship.

So what happened? World chess champion Magnus Carlsen entered both events, and…

A little-known 17-year-old from Uzbekistan made a clean sweep of Magnus Carlsen and the global chess elite on Tuesday, incidentally setting a world age record. Nodirbek Abdusattorov won the World Rapid championship in Warsaw, claiming en route the scalps of Magnus Carlsen and the No 1’s last two challengers, Fabiano Caruana and Ian Nepomniachtchi…

After 21 rounds of three-minute games on Wednesday and Thursday, France’s Maxime Vachier-Lagrave defeated Poland’s Jan-Krzysztof Duda in a tie-break to win the World Blitz title. The 18-year-old world No 2, Alireza Firouzja, was third but Carlsen was well adrift in 12th place. He said: “Some days you just don’t have it. I was nowhere near close to the level I needed to be today.”

At 17 years three months Abdusattorov becomes the youngest ever world champion in open competition… After 13 rounds he was in a quadruple tie on 9.5 points with Carlsen, Caruana and Nepomniachtchi, but the regulations excluded Carlsen and Caruana from the play-off due to their inferior tie-breaks. An angry Carlsen denounced the rules as “idiotic. Either all players on the same amount of points join the play-off or no one does…”

[In the final play-off game] Abdusattorov easily drew with Black, then won the second game despite twice missing mate in two near the end.

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‘A Quadrillion Mainframes On Your Lap’

“Your laptop is way more powerful than you might realize,” writes long-time Slashdot reader fahrbot-bot.
“People often rhapsodize about how much more computer power we have now compared with what was available in the 1960s during the Apollo era. Those comparisons usually grossly underestimate the difference.”

Rodney Brooks, emeritus professor of robotics at MIT (and former director of their AI Lab and CSAIL) explains in IEEE Spectrum:

By 1961, a few universities around the world had bought IBM 7090 mainframes. The 7090 was the first line of all-transistor computers, and it cost US $20 million in today’s money, or about 6,000 times as much as a top-of-the-line laptop today. Its early buyers typically deployed the computers as a shared resource for an entire campus. Very few users were fortunate enough to get as much as an hour of computer time per week.

The 7090 had a clock cycle of 2.18 microseconds, so the operating frequency was just under 500 kilohertz. But in those days, instructions were not pipelined, so most took more than one cycle to execute. Some integer arithmetic took up to 14 cycles, and a floating-point operation could hog up to 15. So the 7090 is generally estimated to have executed about 100,000 instructions per second. Most modern computer cores can operate at a sustained rate of 3 billion instructions per second, with much faster peak speeds. That is 30,000 times as fast, so a modern chip with four or eight cores is easily 100,000 times as fast.

Unlike the lucky person in 1961 who got an hour of computer time, you can run your laptop all the time, racking up more than 1,900 years of 7090 computer time every week….

But, really, this comparison is unfair to today’s computers. Your laptop probably has 16 gigabytes of main memory. The 7090 maxed out at 144 kilobytes. To run the same program would require an awful lot of shuffling of data into and out of the 7090 — and it would have to be done using magnetic tapes . The best tape drives in those days had maximum data-transfer rates of 60 KB per second. Although 12 tape units could be attached to a single 7090 computer, that rate needed to be shared among them. But such sharing would require that a group of human operators swap tapes on the drives; to read (or write) 16 GB of data this way would take three days. So data transfer, too, was slower by a factor of about 100,000 compared with today’s rate.

So now the 7090 looks to have run at about a quadrillionth (10 ** -15) the speed of your 2021 laptop. A week of computing time on a modern laptop would take longer than the age of the universe on the 7090.

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Skillsoft To Acquire Codecademy For $525 Million