Researchers Create Bacteria That Could Protect Your Gut From Antibiotics

In a new study published in the journal Nature Biomedical Engineering, researchers from Harvard and MIT detail work they’ve done on a “living cellular therapeutic device” that promises to protect humans from the harmful side effects antibiotics can have on our guts. Engadget reports: Per Science Daily, they modified a strain of bacteria that is frequently used in cheese production to deliver an enzyme that can break down beta-lactam antibiotics. Many of the most commonly prescribed antibiotics in the US, including penicillin, fall under that family. Using gene editing, they further modified how their bacterium synthesizes the enzyme to prevent it from transferring that capability to other bacteria. The result is a treatment that reduces the harmful effects of antibiotics while still allowing those drugs to do their work.

In a study involving mice, the researchers found their bacteria “significantly” reduced the damage ampicillin did to the test subject’s gut microbes and allowed those communities to recover fully after just three days. By contrast, in mice that only received the antibiotic, the researchers saw a much greater loss of microbial diversity. “We are now focusing on getting these living therapies to patients and are finalizing the design of an effective, short, and inexpensive clinical trial,” said Andres Cubillos-Ruiz, the lead author of the study.

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Bigger Sound In Smaller Packages, As Sonos Buys Mayht For $100 Million

Sonos has acquired Dutch startup Mayht for approximately $100 million in a cash-only deal. “Mayht created a new type of speaker technology that makes it possible to pack a lot more oomph into much smaller spaces, with power savings as a nifty side-effect,” reports TechCrunch. “Specifically, it created a new type of transducer — the foundational element within speakers that create sound. Mayht has re-engineered them to enable smaller and lighter form factors without compromising on quality.” From the report: Interestingly, outside of some reference speakers, the Mayht team was never planning to put its own products out to market, clearly flirting with existing speaker giants for an acquisition. Sonos liked what it saw and decided to put a $100 million ring on it to consummate the relationship, acquiring the startup. The acquisition was formally announced today.

“Mayht’s breakthrough in transducer technology will enable Sonos to take another leap forward in our product portfolio,” said Patrick Spence, CEO of Sonos. “This strategic acquisition gives us more incredible people, technology and intellectual property that will further distinguish the Sonos experience, enhance our competitive advantage, and accelerate our future roadmap.” The Mayht team, in turn, was also pretty psyched to find a corporate partner to bring its tech to market. “We are very excited and proud to become a part of Sonos,” said Scheek. “Our dream has always been to set a new standard in the audio industry. The integration of our technology into Sonos products will further revolutionize high quality sound.”

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Russia Cobbles Together Supercomputing Platform To Wean Off Foreign Suppliers

Russia is adapting to a world where it no longer has access to many technologies abroad with the development of a new supercomputer platform that can use foreign x86 processors such as Intel’s in combination with the country’s homegrown Elbrus processors. The Register reports: The new supercomputer reference system, dubbed “RSK Tornado,” was developed on behalf of the Russian government by HPC system integrator RSC Group, according to an English translation of a Russian-language press release published March 30. RSC said it created RSK Tornado as a “unified interoperable” platform to “accelerate the pace of important substitution” for HPC systems, data processing centers and data storage systems in Russia. In other words, the HPC system architecture is meant to help Russia quickly adjust to the fact that major chip companies such as Intel, AMD and TSMC — plus several other technology vendors, like Dell and Lenovo — have suspended product shipments to the country as a result of sanctions by the US and other countries in reaction to Russia’s invasion of Ukraine.

RSK Tornado supports up to 104 servers in a rack, with the idea being to support foreign x86 processors (should they come available) as well as Russia’s Elbrus processors, which debuted in 2015. The hope appears to be the ability for Russian developers to port HPC, AI and big data applications from x86 architectures to the Elbrus architecture, which, in theory, will make it easier for Russia to rely on its own supply chain and better cope with continued sanctions from abroad. RSK Tornado systems software is RSC proprietary and is currently used to orchestrate supercomputer resources at the Interdepartmental Supercomputer Center of the Russian Academy of Sciences, St Petersburg Polytechnic University and the Joint Institute for Nuclear Research. RSC claims to have also developed its own liquid-cooling system for supercomputers and data storage systems, the latter of which can use Elbrus CPUs too.

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Psilocybin Frees Up Depressed Brain, Study Shows

Psilocybin, a drug found in magic mushrooms, appears to free up the brains of people with severe depression in a way that other antidepressants do not, a study has found. The BBC reports: The results, based on brain scans of 60 people, mean the drug could treat depression in a unique way, the researchers say. Patients with depression are warned not to take psilocybin on their own. A synthetic form of the drug is tested on people in trials under strict medical conditions, with psychological support from experts provided before, during and after it is taken.

With depression, the brain can get stuck in a rut and locked into a particular negative way of thinking, he said. But when given psilocybin, people’s brains opened up and became “more flexible and fluid” up to three weeks later. This could be seen in increased connections between regions of the brain when patients were scanned. These patients were more likely to experience an improvement in mood months later. Similar changes were not seen in the brains of people treated with a standard antidepressant.

The results, published in Nature Medicine, are taken from two studies. In the first, everyone received psilocybin; and in the second — a randomized controlled trial – some were given the drug while others were given a different antidepressant. All participants also received talking therapies with registered mental health professionals. Brain scans were taken before, and then one day or three weeks after taking the therapy.

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El Salvador’s ‘Bitcoin President’ Pressured, Accused of Attacking Civil Liberties

The International Monetary Fund “has indicated it will not give El Salvador a much-needed loan unless it drops bitcoin” as one of the country’s legal tenders, reports the Los Angeles Times. And meanwhile the “bitcoin bond” proposed by El Salvador has been “delayed indefinitely.”

But the government has taken other actions:

After a dramatic spike in killings here over a single weekend last month, Salvadoran President Nayib Bukele’s reaction was swift — and extreme. He sent soldiers into poor neighborhoods to round up thousands of people who he claimed were gang members, then paraded them in front of news cameras in their underwear and handcuffs.
He tweeted pictures of detainees who had been bruised and bloodied by security forces, suggesting they “maybe fell” or “were eating fries with ketchup.” And he started feeding the nation’s prisoners two meals a day instead of three, warning that if violence continued, “I swear to God that they won’t eat a single grain of rice.”

It is a distinct look for Bukele, who has been focused in recent months on presenting himself to the world as a modern tech innovator on a quest to turn El Salvador into a cryptocurrency paradise. Not only is Bukele now embracing the mano duro techniques of past Latin American leaders, he is going much further, using the homicide spree — which left 87 people dead in three days — as a pretext for suspending civil liberties and attacking the press.

In recent days, Bukele and his loyalists in the Legislative Assembly ordered a state of emergency that restricts freedom of association, suspends the norm that detainees be informed of their rights at the moment of arrest and denies prisoners access to lawyers….

That Bukele would use the spate of homicides as a pretext to further consolidate power is no surprise to many of his critics, who believe he may be preparing to stay in office past 2024, when he is supposed to step down, even though El Salvador’s constitution bans consecutive presidential terms.

But they also say that there may be another motive for his new tough-on-crime stance: diverting attention from the deepening failure of his cryptocurrency experiment.

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In California, an Army of Genetically Engineered Mosquitoes Awaits Release

The U.S. government recently gave California approval to release millions of genetically engineered mosquitoes bred by British biotech company Oxitec, reports the Los Angeles Times:

Oxitec, a private company, says its genetically modified bugs could help save half the world’s population from the invasive Aedes aegypti mosquito, which can spread diseases such as yellow fever, chikungunya and dengue to humans. Female offspring produced by these modified insects will die, according to Oxitec’s plan, causing the population to collapse. “Precise. Environmentally sustainable. Non-toxic,” the company says on its website of its product trademarked as the “Friendly” mosquito.

Scientists independent from the company and critical of the proposal say not so fast. They say unleashing the experimental creatures into nature has risks that haven’t yet been fully studied, including possible harm to other species or unexpectedly making the local mosquito population harder to control….

Nathan Rose, Oxitec’s head of regulatory affairs, noted that the company found its mosquito reduced the population in a Brazilian neighborhood by 95% in just 13 weeks. So far, Oxitec has released little of its data from that experiment or from a more recent release in the Florida Keys. It hasn’t yet published any of those results in a peer-reviewed scientific journal — publications that scientists expect when evaluating a new drug or technology….

Among scientists’ concerns is that releasing the genetically modified mosquitoes into neighborhoods could create hybrids that are hardier and more dangerous to humans than the state’s current population…. An EPA spokesperson said regulators expected that mosquitoes with the corporate genes “would disappear from the environment within 10 generations of mosquitoes because they are not able to reproduce as successfully as local populations.” To prove this, the agency has required Oxitec to monitor neighborhoods for mosquitoes that have DNA from its engineered insects until none have been found for at least 10 consecutive weeks.
One bioethicist at Harvard Medical School told the Times that California has never had a case where this breed of mosquitos had actually transmitted disease, and argued that America’s Environmental Protection Agency was “not a modern enough regulatory structure for a very modern and complicated technology.”
After the U.S. government’s approval, the genetically-engineered mosquitors still face several more months of scientific evaluation from California’s Department of Pesticide Regulation.
Thanks to long-time Slashdot reader schwit1 for sharing the link

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Crypto Use Is More Prevalent in Corrupt Countries, IMF Study Finds

“According to a new International Money Fund (IMF) report, cryptocurrency is much more popular in countries with insecure currencies and corrupt governments…” reports The Street, adding that the report concludes “the best way forward is not fight, but to learn how to better regulate cryptocurrency.”

The IMF surveyed more than 110,000 respondents in over 55 countries, polling between 2,000 and 12,000 people in each country, about their cryptocurrency use….
“Crypto usage is empirically associated with higher perceived corruption and more intensive capital controls,” the study’s authors write. “[…] This evidence adds to the case for regulating crypto usage — for example, by requiring intermediaries to implement know-your-customer procedures.”

Bloomberg adds:
The report shows why countries might want to require intermediaries, such as digital currency exchanges, to implement know-your-customer procedures — ID verification standards that are designed to prevent fraud, money laundering and terrorism financing, the organization said. Some countries, like the U.S., have already instituted those kinds of controls.

Nations around the world are struggling over the best way to regulate the $2 trillion crypto market, with the level of oversight varying greatly from one country to another. The findings suggest that crypto assets “may be used to transfer corruption proceeds or circumvent capital controls,” the organization said, without singling out individual countries.

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US President Invokes Emergency Authority Prioritizing Pursuit of EV Battery Minerals

U.S. president Joe Biden “will invoke the Defense Production Act to encourage domestic production of minerals required to make batteries for electric vehicles and long-term energy storage,” reports CNBC.

“It will also help the U.S. minimize dependence on foreign supply chains.”
The president’s order could help companies receive government funding for feasibility studies on projects that extract materials, including lithium, nickel, cobalt, graphite and manganese, for EV production.

The Defense Production Act, established by President Harry Truman during the Cold War, allows the president to use emergency authority to prioritize the development of specific materials for national production…. The administration also said it’s reviewing further uses of the law to “secure safer, cleaner, and more resilient energy for America.”

The transportation sector is one of the largest contributors to U.S. greenhouse gas emissions, representing about one-third of emissions every year. The transition away from gas vehicles to EVs is considered critical to combating human-caused climate change….

The administration in February unveiled a plan to allocate $5 billion to states to fund EV chargers over five years as part of the bipartisan infrastructure package.

The White House said in a statement the move would reduce America’s reliance on China and other countries “for the minerals and materials that will power our clean energy future.”

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The New Silent Majority: People Who Don’t Tweet

An anonymous reader quotes a report from Axios, written by Erica Pandey and Mike Allen: The rising power and prominence of the nation’s loudest, meanest voices obscures what most of us personally experience: Most people are sane and generous — and too busy to tweet. It turns out, you’re right. We dug into the data and found that, in fact, most Americans are friendly, donate time or money, and would help you shovel your snow. They are busy, normal and mostly silent. These aren’t the people with big Twitter followings or cable-news contracts — and they don’t try to pick fights at school board meetings. So the people who get the clicks and the coverage distort our true reality.

Three stats we find reassuring:

1. 75% of people in the U.S. never tweet.
2. On an average weeknight in January, just 1% of U.S. adults watched primetime Fox News (2.2 million). 0.5% tuned into MSNBC (1.15 million).
3. Nearly three times more Americans (56%) donated to charities during the pandemic than typically give money to politicians and parties (21%). The report also highlights a Gallup 2021 poll, showing that 42% of Americans identified as independents.

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