Early Blood Test To Predict Dementia Is Step Closer As Biological Markets Identified

Researchers have made significant progress toward developing a blood test that can predict the risk of dementia up to 15 years before clinical diagnosis. The Guardian reports: Hopes for the test were raised after scientists discovered biological markers for the condition in blood samples collected from more than 50,000 healthy volunteers enrolled in the UK Biobank project. Analysis of the blood identified patterns of four proteins that predicted the onset of dementia in general, and Alzheimer’s disease and vascular dementia specifically, in older age. When combined with more conventional risk factors such as age, sex, education and genetic susceptibility, the protein profiles allowed researchers to predict dementia with an estimated 90% accuracy nearly 15 years before people received clinical confirmation of the disease.

For the latest study, blood samples from 52,645 UK adults without dementia were collected and frozen between 2006 and 2010 and analyzed 10 to 15 years later. More than 1,400 participants went on to develop dementia. Using artificial intelligence, the researchers looked for connections between nearly 1,500 blood proteins and developing dementia years later. Writing in Nature Aging, they describe how four proteins, Gfap, Nefl, Gdf15 and Ltbp2, were present in unusual levels among those who developed all-cause dementia, Alzheimer’s disease or vascular dementia. Higher levels of the proteins were warning signs of disease. Inflammation in the brain can trigger cells called astrocytes to over-produce Gfap, a known biomarker for Alzheimer’s. People with raised Gfap were more than twice as likely to develop dementia than those with lower levels.

Another blood protein, Nefl, is linked to nerve fibre damage, while higher than normal Gdf15 can occur after damage to the brain’s blood vessels. Rising levels of Gfap and Ltbp2 was highly specific for dementia rather than other brain diseases, the scientists found, with changes occurring at least 10 years before people received a dementia diagnosis. The researchers are speaking to companies to develop the test but said the cost, currently at several hundred pounds, would need to come down to make it viable.

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Amazon Hides Cheaper Items With Faster Delivery, Lawsuit Alleges

A class-action lawsuit alleges (PDF) that Amazon manipulates its platform through a biased algorithm to favor the “Buy Box” for items that generate higher fees for Amazon, often leading consumers to overpay for products that could be obtained cheaper and just as quickly from other sellers on the platform. Ars Technica reports: The lawsuit claims that a biased algorithm drives Amazon’s “Buy Box,” which appears on an item’s page and prompts shoppers to “Buy Now” or “Add to Cart.” According to customers suing, nearly 98 percent of Amazon sales are of items featured in the Buy Box, because customers allegedly “reasonably” believe that featured items offer the best deal on the platform.

“But they are often wrong,” the complaint said, claiming that instead, Amazon features items from its own retailers and sellers that participate in Fulfillment By Amazon (FBA), both of which pay Amazon higher fees and gain secret perks like appearing in the Buy Box. “The result is that consumers routinely overpay for items that are available at lower prices from other sellers on Amazonâ”not because consumers don’t care about price, or because they’re making informed purchasing decisions, but because Amazon has chosen to display the offers for which it will earn the highest fees,” the complaint said.

Authorities in the US and the European Union have investigated Amazon’s allegedly anticompetitive Buy Box algorithm, confirming that it’s “favored FBA sellers since at least 2016,” the complaint said. In 2021, Amazon was fined more than $1 billion by the Italian Competition Authority over these unfair practices, and in 2022, the European Commission ordered Amazon to “apply equal treatment to all sellers when deciding what to feature in the Buy Box.” These investigations served as the first public notice that Amazon’s Buy Box couldn’t be trusted, customers suing said. Amazon claimed that the algorithm was fixed in 2020, but so far, Amazon does not appear to have addressed all concerns over its Buy Box algorithm. As of 2023, European regulators have continued pushing Amazon “to take further action to remedy its Buy Box bias in their respective jurisdictions,” the customers’ complaint said.

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Computer Simulations of Atlantic Ocean Currents Finds Collapse Could Happen in Our Lifetime

An anonymous reader shared this report from the Associated Press:

An abrupt shutdown of Atlantic Ocean currents that could put large parts of Europe in a deep freeze is looking a bit more likely and closer than before as a new complex computer simulation finds a “cliff-like” tipping point looming in the future. A long-worried nightmare scenario, triggered by Greenland’s ice sheet melting from global warming, still is at least decades away if not longer, but maybe not the centuries that it once seemed, a new study in Friday’s Science Advances finds.

The study, the first to use complex simulations and include multiple factors, uses a key measurement to track the strength of vital overall ocean circulation, which is slowing. A collapse of the current — called the Atlantic Meridional Overturning Circulation or AMOC — would change weather worldwide because it means a shutdown of one of key the climate and ocean forces of the planet. It would plunge northwestern European temperatures by 9 to 27 degrees (5 to 15 degrees Celsius) over the decades, extend Arctic ice much farther south, turn up the heat even more in the Southern Hemisphere, change global rainfall patterns and disrupt the Amazon, the study said. Other scientists said it would be a catastrophe that could cause worldwide food and water shortages.

“We are moving closer (to the collapse), but we we’re not sure how much closer,” said study lead author Rene van Westen, a climate scientist and oceanographer at Utrecht University in the Netherlands. “We are heading towards a tipping point.” When this global weather calamity — grossly fictionalized in the movie “The Day After Tomorrow” — may happen is “the million-dollar question, which we unfortunately can’t answer at the moment,” van Westen said. He said it’s likely a century away but still could happen in his lifetime. He just turned 30.

“It also depends on the rate of climate change we are inducing as humanity,” van Westen said.

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San Francisco Mob Lights Driverless Waymo Car on Fire

Last night in San Francisco’s Chinatown, “A person jumped on the hood of a Waymo driverless taxi and smashed its windshield…” reports the Verge, “generating applause before a crowd formed around the car and covered it in spray paint, breaking its windows, and ultimately set it on fire.”

The fire department arrived minutes later, according to a report in The Autopian, but by then flames had already fully engulfed the car…. Waymo representative Sandy Karp told The Verge via email that the fully autonomous car “was not transporting any riders” when it was attacked and fireworks were tossed inside the car, sparking the flames…

The fire takes place against the backdrop of simmering tension between San Francisco residents and automated vehicle operators… Just last week, a Waymo car struck a cyclist who had reportedly been following behind a truck turning across its path.

The “burnt-out husk of the electric Waymo Jaguar” appears in a video posted on YouTube, according to the article. “Another set of videos posted by software developer Michael Vendi gives a view into the scene as it played out and the fire grew.”

San Francisco’s 49ers play in the Super Bowl this afteroon, so last night’s celebrations for Chinese New Year could be followed by additional celebrations tonight. Police Chief Bill Scott is already urging residents to behave responsibly. “Please don’t light anything on fire.”

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California Bill Would Require Computer Science For High School Graduation

At a press conference last week, a California Assemblymember joined the State Superintendent of Public Instruction in announcing a bill that, if passed, would require every public high school to teach computer science. (And establish CS as a high school graduation requirement by the 2030-31 school year.)

Long-time Slashdot reader theodp says he noticed posters with CS-education advocacy charts and stats “copied verbatim” from the tech giant-backed nonprofit Code.org. (And “a California Dept. of Education news release also echoed Code.org K-12 CS advocacy factoids.”)

The announcement came less than two weeks after Code.org CEO Hadi Partovi — whose goal is to make CS a HS graduation requirement in all 50 states by 2030 — was a keynote speaker at the Association of California School Administrators Superintendents’ Symposium. Even back in an October 20 Facebook post, [California state assemblyman] Berman noted he’d partnered with Code.org on legislation in the past and hinted that something big was in the works on the K-12 CS education front for California. “I had the chance to attend Code.org’s 10th anniversary celebration and chat with their founder, Hadi Partovi, as well as CS advocate Aloe Blacc. They’ve done amazing work expanding access to computer science education… and I’ve been proud to partner with them on legislation to do that in CA. More to come!”

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In Big Tech’s Backyard, a California State Lawmaker Unveils a Landmark AI Bill

An anonymous reader shared this report from the Washington Post:

A California state lawmaker introduced a bill on Thursday aiming to force companies to test the most powerful artificial intelligence models before releasing them — a landmark proposal that could inspire regulation around the country as state legislatures increasingly tackle the swiftly evolving technology.

The new bill, sponsored by state Sen. Scott Wiener, a Democrat who represents San Francisco, would require companies training new AI models to test their tools for “unsafe” behavior, institute hacking protections and develop the tech in such a way that it can be shut down completely, according to a copy of the bill. AI companies would have to disclose testing protocols and what guardrails they put in place to the California Department of Technology. If the tech causes “critical harm,” the state’s attorney general can sue the company.

Wiener’s bill comes amid an explosion of state bills addressing artificial intelligence, as policymakers across the country grow wary that years of inaction in Congress have created a regulatory vacuum that benefits the tech industry. But California, home to many of the world’s largest technology companies, plays a singular role in setting precedent for tech industry guardrails. “You can’t work in software development and ignore what California is saying or doing,” said Lawrence Norden, the senior director of the Brennan Center’s Elections and Government Program… Wiener says he thinks the bill can be passed by the fall.
The article notes there’s now 407 AI-related bills “active in 44 U.S. states (according to an analysis by an industry group called BSA the Software Alliance) — with several already signed into law. “The proliferation of state-level bills could lead to greater industry pressure on Congress to pass AI legislation, because complying with a federal law may be easier than responding to a patchwork of different state laws.”
Even the proposed California law “largely builds off an October executive order by President Biden,” according to the article, “that uses emergency powers to require companies to perform safety tests on powerful AI systems and share those results with the federal government. The California measure goes further than the executive order, to explicitly require hacking protections, protect AI-related whistleblowers and force companies to conduct testing.”

They also add that as America’s most populous U.S. state, “California has unique power to set standards that have impact across the country.” And the group behind last year’s statement on AI risk helped draft the legislation, according to the article, though Weiner says he also consulted tech workers, CEOs, and activists. “We’ve done enormous stakeholder outreach over the past year.”

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Nvidia is Forming a New Business Unit to Make Custom Chips

An anonymous reader shared this report from Reuters:

Nvidia is building a new business unit focused on designing bespoke chips for cloud computing firms and others, including advanced AI processors, nine sources familiar with its plans told Reuters. The dominant global designer and supplier of AI chips aims to capture a portion of an exploding market for custom AI chips and shield itself from the growing number of companies pursuing alternatives to its products.

The Santa Clara, California-based company controls about 80% of high-end AI chip market, a position that has sent its stock market value up 40% so far this year to $1.73 trillion after it more than tripled in 2023. Nvidia’s customers, which include ChatGPT creator OpenAI, Microsoft, Alphabet, and Meta Platforms, have raced to snap up the dwindling supply of its chips to compete in the fast-emerging generative AI sector. Its H100 and A100 chips serve as a generalized, all-purpose AI processor for many of those major customers. But the tech companies have started to develop their own internal chips for specific needs. Doing so helps reduce energy consumption, and potentially can shrink the cost and time to design.

Nvidia is now attempting to play a role in helping these companies develop custom AI chips that have flowed to rival firms such as Broadcom and Marvell Technology, said the sources, who declined to be identified because they were not authorized to speak publicly…
Nvidia moving into this territory has the potential to eat into Broadcom and Marvell sales.

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Apple Is Settling Chip Secrets Theft Case Against Startup Rivos, Former Employees

In 2022 Apple filed a lawsuit against startup Rivos. The lawsuit said that in one year Rivos had hired more than 40 former Apple employees to work on competing system-on-a-chip technology, according to Reuters, “and that at least two former Apple engineers took gigabytes of confidential information with them to Rivos.”

But Friday Bloomberg reported that the two companies told a judge that they’d “signed an agreement that potentially settles the case.”

“The agreement provides for remediation of Apple confidential information based on a forensic examination of Rivos systems and other activities,” according to the filing in federal court in San Jose, California. “The parties currently are working through that process.”

More details from Engadget:

Apple also accused the defendant of instructing the employees it hired away to steal presentations and other proprietary information for unreleased iPhone chip designs that cost billions of dollars to develop. Rivos countersued Apple last year, accusing the larger company of restricting employees’ ability to work elsewhere and of hindering emerging startups’ growth by using anticompetitive measures.
The court dismissed Apple’s trade secret claims against Rivos in April 2023, though the company was allowed to file a revised complaint. Apple already settled with its six former employees who filed a countersuit against the iPhonemaker along with Rivos after they dropped their claims against each other last month.

Both companies are now requesting the court to put their cases on hold until March 15, when they expect the settlement to be completed.

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Instagram and Threads Will Stop Recommending Political Content

In a blog post today, Meta announced that it’ll stop showing political content across Instagram and Threads unless users explicitly choose to have it recommended to them. The Verge reports: Meta announced that it’s expanding an existing Reels policy that limits political content from people you’re not following (including posts about social issues) from appearing in recommended feeds to more broadly cover the company’s Threads and Instagram platforms. “Our goal is to preserve the ability for people to choose to interact with political content, while respecting each person’s appetite for it,” said Instagram head Adam Mosseri, announcing on Threads that the changes will be applied over the next few weeks. Facebook is also expected to roll out these new controls at a later, undisclosed date.

Users who still want to have content “likely to mention governments, elections, or social topics that affect a group of people and/or society at large” recommended to them can choose to turn off this limitation within their account settings. The changes will apply to public accounts when enabled and only in places where content is being recommended, such as Explore, Reels, in-feed recommendations, and suggested users. The update won’t change how users view content from accounts they choose to follow, so accounts that aren’t eligible to be recommended can still post political content to their followers via their feed and Stories.

For creators, Meta says that “if your account is not eligible to be recommended, none of your content will be recommended regardless of whether or not all of your content goes against our recommendations guidelines.” When these changes do go live, professional accounts on Instagram will be able to use the Account Status feature to check if posting political content is impacting their eligibility for recommendation. Professional accounts can also use Account Status to contest decisions that revoke this eligibility, alongside editing, removing, or pausing politically related posts until the account is eligible to be recommended again.

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