MS Symptoms May Have Been ‘Reversed’ In Immunotherapy Breakthrough

A new immunotherapy that targets cells infected with Epstein-Barr Virus (EBV) has halted the progression of multiple sclerosis (MS) in a small trial. Perhaps even more incredibly, in some patients, it is possible that symptoms of MS were actually reversed, though this was not fully identified in the most recent presentation of results (PDF). IFLScience reports: [S]ignificant evidence has linked infection of EBV and the eventual development of MS. […] Attempting to “transform treatment of Multiple Sclerosis,” Atara Biotherapeutics has developed an allogeneic T-cell therapy called ATA188. The concept is simple — when cells are infected with EBV, they express small proteins called antigens on the cell surface, and the immunotherapy contains immune cells that target and destroy them.

In a trial of 24 patients who received the therapy, 20 saw improvements or stability in their symptoms and no fatal or serious adverse effects were reported. Early brain scans suggest that some damaged nerve cells may have been “repaired” by the therapy in a process called remyelination, which could mean a reversal of damage caused by MS in the nervous system, but this has not yet been confirmed. While the results are extremely promising, it is an early Phase 1 trial with a small sample size and no placebo or control group, so it is unclear whether the results are significant at this stage. However, it is unlikely that this repair would occur naturally, suggesting the therapy is having a beneficial effect on some level.

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Reddit Adds Comment Searching To Help Improve Search Results

Today, Reddit is updating its search feature to index comments. The Verge reports: For the first time, users will have an option to pull results from replies to posts, making it less of a hassle to find something specific outside of general Reddit posts, communities, and people. The rollout is Reddit’s latest change to help users encounter content from outside their usual subreddits following the addition of a discovery tab on its mobile app in January.

Reddit says that in a user survey last year, the ability to search comments was one of the top results. During “limited initial testing,” Reddit claimed 26,000 users went on to use the feature against five billion comments. Right now, the new ability is available globally for users searching on Reddit’s desktop website, but not via its apps. The company “is also updating its search experience to help users find more relevant search results written by real people,” adds The Verge. “For example, when searching for something, instead of showing search results with that exact wording, related results will pop up instead to make the search less restrictive.”

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ACE Shuts Down Massive Pirate Site After Locating Owner In Remote Peru

As part of its global anti-piracy mission, the Alliance for Creativity and Entertainment (ACE) has been trying to shut down Pelisplushd.net, a massive pirate streaming site with roughly 70 million visits per month. After tracking down its operator in the remote countryside of Peru, the anti-piracy group says the site is no more. TorrentFreak reports: In a statement published Wednesday, ACE officially announced that it was behind the closure of Pelisplushd.net. The anti-piracy group labeled the platform the second-largest Spanish-language ‘rogue website’ in the entire Latin American region with 383.5 million visits in the past six months and nearly 75 million visits in February 2022. In Mexico alone, the site had more visitors than hbomax.com, disneyplus.com and primevideo.com, a clear problem for those platforms which are all ACE members.

“This is a huge win for the ACE team based in Latin America as we work to protect the legitimate digital ecosystem throughout the region,” said Jan van Voorn, Executive Vice President and Chief of Global Content Protection for the Motion Picture Association. “The successful action against the operator of Pelisplushd.net was only made possible because of evidence that we gathered from previous operations conducted in other countries in Latin America. “This speaks volumes about ACE’s ability to crack current cases utilizing years of past gathered intelligence and highlights the global, strategic approach that determines our actions around the world.”

The operator of Pelisplushd is yet to be named but ACE reveals that after a positive identification, the anti-piracy group tracked him down to the “remote countryside of Peru.” That took place in March and soon after, ACE says the operator agreed to turn over his domains. As far as we can tell the main domain at Pelisplushd.net is not yet completely in ACE/MPA hands but a full transfer will probably take place later.

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‘Club Penguin Rewritten’ Allegedly Shut Down By Disney, Website Seized By London Police

“Club Penguin Rewritten,” a popular remake of Club Penguin enjoyed by thousands of gamers, has been seized by the City of London Police, with three people in connection with the site’s shuttering reportedly arrested for allegedly distributing copyrighted material. “Over 140,000 users were members of a Discord server for the game until today, when every message on the Discord disappeared,” reports TechCrunch. From the report: In 2007, Disney purchased Club Penguin — the children’s RPG that served as my first introduction to online fandom — for a whopping $700 million. Even then, as a child with little context about tech industry acquisitions, the purchase seemed foreboding (at least my friends thought so on the Miniclip forums, where I fraudulently claimed to be 13). But eventually, those of us who were dedicated fans of virtual sledding games and dance parties grew out of it, and after once boasting 200 million users, the game was shut down due to lack of interest in 2017. Disney tried to shuttle remaining players to a new mobile game called Club Penguin Island, but it only lasted for a year. But ever since the end of Club Penguin — when the iceberg finally tipped in a strangely emotional moment — there have always been remakes out there for nostalgic adults to relive their days of collecting puffles, dancing in the pizza shop and speed-running bans.

Only one message on the Discord remains, posted early this morning by an admin: “CPRewritten is shutting down effective immediately due to a full request by Disney,” the admin said. “We have voluntarily given control over the website to the police for them to continue their copyright investigation.” TechCrunch reached out to the City of London Police and Disney to verify these claims but did not hear back before publication. In 2020, Disney shut down “Club Penguin Online,” another copy of the game that acquired over a million new players during the pandemic.

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California Weighs Shift To 32-Hour Work Week For Larger Companies

Assembly member Cristina Garcia has cosponsored a bill to make the state’s official workweek 32 hours for companies with 500 or more employees. CBS News reports: Any work done past that cutoff would come with a hefty raise: Employers would be required to pay time-and-a-half to workers whose hours run over 32 a week. And work stretching past 12 hours a day or into seven days a week would be paid at double the normal wage. Employers subject to the law, which would apply to 20% of California’s workforce, also would be barred from reducing people’s pay if they work less than their standard workweek, Garcia told CBS News. The bill would not apply to workers who are represented by a union and covered by a collective bargaining agreement.

The proposed law would cover about 2,600 companies in California, according to the Employment Development Department (PDF). The California Chamber of Commerce called it a “job killer,” saying it would make hiring more expensive and lead to a drop in jobs in California. “Labor costs are often one of the highest costs a business faces,” Ashley Hoffman, policy advocate with the Chamber, wrote to bill cosponsor Evan Low last week. “[B]usinesses often operate on thin profit margins and… the number of employees you have does not dictate financial success,” she wrote.

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Russian Tech Industry Faces ‘Brain Drain’ As Workers Flee

mspohr shares a report from the New York Times: In early March, days after Russia invaded Ukraine and began cracking down on dissent at home, Konstantin Siniushin, a venture capitalist in Riga, Latvia, helped charter two planes out of Russia to help people flee. Both planes departed from Moscow, carrying tech workers from the Russian capital as well as St. Petersburg, Perm, Ekaterinburg and other cities. Together, the planes moved about 300 software developers, entrepreneurs and other technology specialists out of the country, including 30 Russian workers from start-ups backed by Mr. Siniushin. The planes flew south past the Black Sea to Yerevan, the capital of Armenia, where thousands of other Russian tech workers fled in the weeks after the invasion. Thousands more flew to Georgia, Turkey, the United Arab Emirates and other countries that accept Russian citizens without visas.

By March 22, a Russian tech industry trade group estimated that between 50,000 and 70,000 tech workers had left the country and that an additional 70,000 to 100,000 would soon follow. They are part of a much larger exodus of workers from Russia, but their departure could have an even more lasting impact on the country’s economy. The long-run impact may be more significant than the short-run impact,” said Barry Ickes, head of the economics department at Pennsylvania State University, who specializes in the Russian economy. “Eventually, Russia has to diversify its economy away from oil and gas, and it has to accelerate productivity growth. Tech was a natural way of doing that.” Before all this started, Russia had such a strong technology base,” [Artem Taganov, founder and chief executive of a Russian start-up called HintEd] said. “Now, we have a brain drain that will continue for the next five to 10 years.”

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Researchers Create Bacteria That Could Protect Your Gut From Antibiotics

In a new study published in the journal Nature Biomedical Engineering, researchers from Harvard and MIT detail work they’ve done on a “living cellular therapeutic device” that promises to protect humans from the harmful side effects antibiotics can have on our guts. Engadget reports: Per Science Daily, they modified a strain of bacteria that is frequently used in cheese production to deliver an enzyme that can break down beta-lactam antibiotics. Many of the most commonly prescribed antibiotics in the US, including penicillin, fall under that family. Using gene editing, they further modified how their bacterium synthesizes the enzyme to prevent it from transferring that capability to other bacteria. The result is a treatment that reduces the harmful effects of antibiotics while still allowing those drugs to do their work.

In a study involving mice, the researchers found their bacteria “significantly” reduced the damage ampicillin did to the test subject’s gut microbes and allowed those communities to recover fully after just three days. By contrast, in mice that only received the antibiotic, the researchers saw a much greater loss of microbial diversity. “We are now focusing on getting these living therapies to patients and are finalizing the design of an effective, short, and inexpensive clinical trial,” said Andres Cubillos-Ruiz, the lead author of the study.

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Cop Admits To Playing Copyrighted Music Through Squad Car PA To Keep Videos Off YouTube

A police officer in Santa Ana, California, admitted to blaring Disney favorites from a squad car PA system in an attempt to keep citizens’ videos of their actions off of YouTube. Jalopnik reports: It just so happens they woke up a sleeping city council member, who took police to task for their annoying and suspicious tactic. Using copyright infringement against those who record police actions hasn’t really work so far, which may be why this officer decided to really blare Disney tunes during an investigation of a car theft. At the moment, the video posted by Santa Ana Audits is still up after being posted six days ago, so it’s safe to say this officer woke up an entire community for nothing.

Santa Ana PD release a statement on Twitter acknowledging the video. Santa Ana PD told Vice that using squad car audio system is not department policy. YouTube won’t always remove a video for copyright infringement. Sometimes the site will place an ad on the video, with proceeds going to the copyright holder.

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Amazon Workers Made Up Almost Half of All Warehouse Injuries Last Year

Amazon workers only make up a third of US warehouse employees, but in 2021, they suffered 49 percent of the injuries for the entire warehouse industry, according to a report by advocacy group Strategic Organizing Center (or SOC). The Verge reports: After analyzing data from the Occupational Safety and Health Administration (OSHA), the union coalition found that Amazon workers are twice as likely to be seriously injured than people who work in warehouses for other companies. The report considers “serious injuries” to be ones where workers either have to take time off to recover or have their workloads reduced, following OSHA’s report classification (pdf) of “cases with days away from work” and “cases with job transfer or restriction.” The data shows that, over time, the company has been shifting more toward putting people on light duty, rather than having them take time off. The report authors also note that Amazon workers take longer to recover from injuries than employees at other companies: around 62 days on average, versus 44 across the industry.

Amazon employees have said it’s not the work itself that’s particularly dangerous but rather the grueling pace the company’s automated systems demand. Amazon actually had workers go slower in 2020 to help combat COVID-19, which accounts for the notably lower injury rates that year. But, as the report notes, the injuries increased by around 20 percent between 2020 and 2021 as the company resumed its usual pace — though the injury rates for 2021 were still lower than they were in 2019. […] Unfortunately, this study’s results tell the same story we’ve been hearing for years. Even with its reduced injury rates in 2020, Amazon workers were still hurt twice as often as other warehouse workers, according to SOC. Further reading: Amazon Workers At 100 More Facilities Want To Unionize (Yahoo Finance)

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Psilocybin Frees Up Depressed Brain, Study Shows

Psilocybin, a drug found in magic mushrooms, appears to free up the brains of people with severe depression in a way that other antidepressants do not, a study has found. The BBC reports: The results, based on brain scans of 60 people, mean the drug could treat depression in a unique way, the researchers say. Patients with depression are warned not to take psilocybin on their own. A synthetic form of the drug is tested on people in trials under strict medical conditions, with psychological support from experts provided before, during and after it is taken.

With depression, the brain can get stuck in a rut and locked into a particular negative way of thinking, he said. But when given psilocybin, people’s brains opened up and became “more flexible and fluid” up to three weeks later. This could be seen in increased connections between regions of the brain when patients were scanned. These patients were more likely to experience an improvement in mood months later. Similar changes were not seen in the brains of people treated with a standard antidepressant.

The results, published in Nature Medicine, are taken from two studies. In the first, everyone received psilocybin; and in the second — a randomized controlled trial – some were given the drug while others were given a different antidepressant. All participants also received talking therapies with registered mental health professionals. Brain scans were taken before, and then one day or three weeks after taking the therapy.

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